| Size | Price | Stock | Qty |
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| 100mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
O. Eugenol and gratissimum essential oil both work well to prevent H from changing into another species. contortus eggs, indicating possible application in the management of small ruminant gastrointestinal helminthiasis. Eugenol and essential oils had the strongest inhibitory impact at a concentration of 0.50% [1]. Eugenol inhibits the xanthine-xanthine oxidase system's ability to produce superoxide anions by 50% at a dose of 250 μM. Additionally, ethanol can reduce the synthesis of hydroxyl free radicals by 70%. The measurement of OH radical generation involves hydroxylating salicylate to 2,3-dihydroxybenzoate, and 46% of OH radical formation is inhibited by 250 μM eugenol [2]. Eugenol has antioxidant properties, but it also modulates the brain's monoaminergic pathways and HPA axis, which may help avoid gastrointestinal dysfunction similar to IBS that is brought on by RS. Like ondansetron, eugenol (50 mg/kg) decreased the rise in fecal particles brought on by RS by 80%. Eugenol affects the PFC and amygdala's serotonin pathway and reduces stress-induced increases in plasma corticosterone by 80%. Eugenol strengthens antioxidant defense mechanisms throughout the brain and reduces norepinephrine alterations brought on by stress [3].
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| ln Vivo |
Eugenol (33 mg/kg) given orally for two days considerably reduced knee edema, which persisted to do so at the conclusion of the treatment. After two days, rats with mycobacterial arthritis treated with eugenol showed a considerable reduction in paw swelling [4].
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| References |
[1]. Pessoa LM, et al. Anthelmintic activity of essential oil of Ocimum gratissimum Linn. and eugenol against Haemonchus contortus. Vet Parasitol. 2002 Oct 16;109(1-2):59-63.
[2]. Reddy AC, et al. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygenspecies and the oxidation of ferrous iron. Mol Cell Biochem. 1994 Aug 17;137(1):1-8. [3]. Garabadu D, et al. Protective effect of eugenol against restraint stress-induced gastrointestinal dysfunction: Potential use in irritable bowel syndrome. Pharm Biol. 2015 Jul;53(7):968-74. [4]. Sharma JN, et al. Suppressive effects of eugenol and ginger oil on arthritic rats. Pharmacology. 1994 Nov;49(5):314-8 |
| Molecular Formula |
C10H12O2
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|---|---|
| Molecular Weight |
164.2011
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| CAS # |
97-53-0
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| Related CAS # |
Eugenol-d3;1335401-17-6
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
O(C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])C([H])=C([H])[H])O[H]
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~609.01 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3.25 mg/mL (19.79 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 3.25 mg/mL (19.79 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 3.25 mg/mL (19.79 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.0901 mL | 30.4507 mL | 60.9013 mL | |
| 5 mM | 1.2180 mL | 6.0901 mL | 12.1803 mL | |
| 10 mM | 0.6090 mL | 3.0451 mL | 6.0901 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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