Size | Price | Stock | Qty |
---|---|---|---|
5mg |
|
||
10mg |
|
||
25mg |
|
||
50mg |
|
||
100mg |
|
||
250mg |
|
||
500mg |
|
||
1g |
|
||
Other Sizes |
|
Purity: ≥98%
ln Vitro |
F1063-0967 is an IC50 of 11.62 μM for dual-specificity phosphatase 26 (DUSP26) inhibitors. F1063-0967 strongly promotes apoptosis in IMR32 cells at concentrations greater than 0.1 μM. With an IC50 value of 4.13 μM, F1063-0967 causes apoptosis in the IMR-32 cell line. F1063-0967 exhibits negligible inhibitory effect on the SH-SY5Y cell line and no effect on the HL7702 cell line [1].
|
---|---|
References |
[1]. Ren JX, et al. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. Biomed Pharmacother. 2017 May;89:376-385
|
Molecular Formula |
C24H24N2O5S2
|
---|---|
Molecular Weight |
484.585
|
Exact Mass |
484.11
|
Elemental Analysis |
C, 59.49; H, 4.99; N, 5.78; O, 16.51; S, 13.23
|
CAS # |
613225-56-2
|
Related CAS # |
613225-56-2;
|
Appearance |
Solid powder
|
SMILES |
O=C(O)C1=CC=C(NC(CCCCCN(C/2=O)C(SC2=C/C3=CC=C(C)C=C3)=S)=O)C=C1O
|
Synonyms |
F1063-0967; F1063 0967; F10630967; F-10630967; F 10630967;
|
HS Tariff Code |
2934.99.9001
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
DMSO : ~100 mg/mL (~206.36 mM)
|
---|---|
Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (5.16 mM) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.0636 mL | 10.3180 mL | 20.6360 mL | |
5 mM | 0.4127 mL | 2.0636 mL | 4.1272 mL | |
10 mM | 0.2064 mL | 1.0318 mL | 2.0636 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.