Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Fostemsavir Tris (BMS-663068 trisaminomethane or tromethamine or THAM) is the trisaminomethane salt of Fostemsavir (BMS663068; BMS-663068; Rukobia) which is an anti-HIV medication marketed in 2020. Fostemsavir is the phosphonooxymethyl prodrug of BMS-626529 which is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
ln Vivo |
Fostemsavir Tris exhibits good antiviral action (IC50, <100 nM) against drug-susceptible viruses in infected patients [1].
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References |
[1]. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.
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Molecular Formula |
C29H37N8O11P
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Molecular Weight |
704.6248
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Exact Mass |
704.23
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Elemental Analysis |
C, 49.43; H, 5.29; N, 15.90; O, 24.98; P, 4.40
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CAS # |
864953-39-9
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Related CAS # |
Temsavir;701213-36-7;Fostemsavir;864953-29-7
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Appearance |
Solid powder
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SMILES |
P(=O)(O[H])(O[H])OC([H])([H])N1C([H])=C(C(C(N2C([H])([H])C([H])([H])N(C(C3C([H])=C([H])C([H])=C([H])C=3[H])=O)C([H])([H])C2([H])[H])=O)=O)C2C(=C([H])N=C(C1=2)N1C([H])=NC(C([H])([H])[H])=N1)OC([H])([H])[H].O([H])C([H])([H])C(C([H])([H])O[H])(C([H])([H])O[H])N([H])[H]
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InChi Key |
RRGJSMBMTOKHTE-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C25H26N7O8P.C4H11NO3/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17;5-4(1-6,2-7)3-8/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38);6-8H,1-3,5H2
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Chemical Name |
1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-((phosphonooxy)methyl)-1H-pyrrolo(2,3-c)pyridin-3-yl)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
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Synonyms |
Fostemsavir tromethamine; BMS663068; BMS-663068; BMS 663068; BMS-663068-03; GSK3684934A
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~125 mg/mL (~177.40 mM)
H2O : ~100 mg/mL (~141.92 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (2.95 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (2.95 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (2.95 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 50 mg/mL (70.96 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.4192 mL | 7.0960 mL | 14.1920 mL | |
5 mM | 0.2838 mL | 1.4192 mL | 2.8384 mL | |
10 mM | 0.1419 mL | 0.7096 mL | 1.4192 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.