Size | Price | Stock | Qty |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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Purity: ≥98%
Gabapentin HCl (Neurontin), the hydrochloride salt of gabapentin which is a GABA analogue, is an orally bioavailable and approved medication used to treat seizures and neuropathic pain. Gabapentin is a major inhibitory neurotransmitter that functions by binding to the GABA receptors located in the spinal cord. Gabapentin also binds to a novel site on voltage-sensitive Ca2+ channels. Additionally, Gabapentin demonstrates inhibition of dopamine release from caudate nucleus, prevent neuronal cell death, and is antinociceptive. It is structurally similar to GABA and is reported in various research studies to increase GABA concentrations within the brain.
ln Vitro |
The concentration-dependent inhibition of the K+-induced [Ca2+]i increase in synaptosomes (IC50=14 μM; maximal inhibition by 36%) is produced by gabapentin (0-300 μM) hydrochloride[1]. In neocortical slices, gabapentin hydrochloride (100 μM) reduces endogenous aspartate and glutamate release triggered by K+ by 16 and 18%, respectively[1]. The K+-evoked [3H]-noradrenaline release in neocortical slices is lessened by gabapentin hydrochloride (0-1000 μM; maximal inhibition of 46%), but not from synaptosomes[1].
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ln Vivo |
The spatial and affective cognitive performance of naive mice in the Morris water maze (MWM), passive avoidance (PA), and modified elevated plus maze (mEPM) tasks is improved by gabapentin hydrochloride (5 and 10 mg/kg; ip; once; male BALB/c mice)[2]. Gabapentin hydrochloride (1–100 mg/kg; ip; once; male mice) provides a dose-dependent analgesic effect and lessens writhing[3].
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Animal Protocol |
Animal/Disease Models: Male balb/c (Bagg ALBino) mouse ( 35-45 g)[2]
Doses: 5 and 10 mg/kg Route of Administration: intraperitoneal (ip)injection; once Experimental Results: Increased the time spent in target quadrant and diminished the distance to platform in MWM test . diminished the transfer latency on second day in mEPM test . Prolonged retention latency in PA test . Animal/Disease Models: Male mice (26-30 g)[3] Doses: 1, 5, 10, 50 and 100 mg/kg Route of Administration: intraperitoneal (ip)injection; once Experimental Results: Produced 45-70% inhibition of writhing. |
References |
[1]. Fink K, et, al. Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br J Pharmacol. 2000 Jun;130(4):900-6.
[2]. Celikyurt IK, et, al. Gabapentin, A GABA analogue, enhances cognitive performance in mice. Neurosci Lett. 2011 Apr 1;492(2):124-8. [3]. Meymandi MS, et, al. Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. Eur J Anaesthesiol. 2008 Feb;25(2):129-34. |
Molecular Formula |
C9H17NO2.HCL
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Molecular Weight |
207.7
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CAS # |
60142-95-2
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SMILES |
O=C(O)CC1(CN)CCCCC1.[H]Cl
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InChi Key |
XBUDZAQEMFGLEU-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C9H17NO2.ClH/c10-7-9(6-8(11)12)4-2-1-3-5-9;/h1-7,10H2,(H,11,12);1H
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Chemical Name |
1-(Aminomethyl)cyclohexaneacetic acid HCl
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 4.8146 mL | 24.0732 mL | 48.1464 mL | |
5 mM | 0.9629 mL | 4.8146 mL | 9.6293 mL | |
10 mM | 0.4815 mL | 2.4073 mL | 4.8146 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
(a) Trace showing changes in fluorescence ratio produced by changes in KCl in imaging experiments. (b) Graph showing linear correlation between change in fluorescence ratio and membrane potential at varying concentrations of K+. |