Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Gallopamil HCl (Methoxyverapamil HCl), a methoxy analog of Verapamil, is a a coronary vasodilator and a phenylalkylamine calcium antagonist. Gallopamil HCl inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil HCl is a highly potent antiarrhythmic and vasodilator agent.
ln Vivo |
Intravenous (IV) galopamil hydrochloride (methoxyverapamil hydrochloride; 0.2 mg/kg; for 5 minutes) fully avoids fibrillation (VF) and considerably lowers ventricular tachycardia (VT). Without appreciably altering heart rate, gallopamil dramatically lowers both the systolic and diastolic blood pressure measured five minutes after injection [3].
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Animal Protocol |
Animal/Disease Models: Male Wistar rats, weight 290-370 g [3]
Doses: 0.2 mg/kg Route of Administration: intravenous (iv) (iv)injection; 5 minutes Experimental Results: VT was Dramatically diminished and VF was completely prevented. |
References |
[1]. Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115.
[2]. Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. [3]. Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21. |
Molecular Formula |
C₂₈H₄₁CLN₂O₅
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Molecular Weight |
521.08854
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CAS # |
16662-46-7
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Related CAS # |
Gallopamil;16662-47-8
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
c1(OC)c(OC)cc(cc1OC)[C@@](CCC[N@@](CCc1ccc(c(c1)OC)OC)C)(C(C)C)C#N.Cl
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InChi Key |
OKCRIUNHEQSXFD-UHFFFAOYSA-N
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InChi Code |
1S/C28H40N2O5.ClH/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5/h10-11,16-18,20H,9,12-15H2,1-8H31H
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Chemical Name |
Benzeneacetonitrile,
alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-,
monohydrochloride
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Synonyms |
Methoxyverapamil,Algocor, D 600 Hydrochloride, Gallopamil HCl, Gallopamil hydrochloride, Procorum
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~191.91 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.80 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.80 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (4.80 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.9191 mL | 9.5953 mL | 19.1905 mL | |
5 mM | 0.3838 mL | 1.9191 mL | 3.8381 mL | |
10 mM | 0.1919 mL | 0.9595 mL | 1.9191 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.