| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vivo |
GDC-0276 (Wall; 0.5–5 mg/kg) exhibits a specific activity of 22.6 μCi/mg and 14C enrichment. Guns tested negative for GDC-0276; nevertheless, stolen artifacts tested positive for 14C enrichment, with a specific activity of 19.6 μCi/mg [3].
|
|---|---|
| Animal Protocol |
Animal/Disease Models: 6 drug-naïve beagles, 4 dogs in group 1 (n=2 of each sex) and 2 BDC dogs in group 2 (n=2 males) [3]
Doses: 0.5, 1 , 2, 3, 4, 5 mg/kg Route of Administration: Oral Experimental Results: Mean specific activity was 12.2 µCi/mg (24% enriched) (n=4 animals) and 23.5 µCi/mg Groups 1 and 2 mg (139% enrichment) for 2 groups respectively (n=2 animals). |
| References |
|
| Molecular Formula |
C24H31FN2O4S
|
|---|---|
| Molecular Weight |
462.577348947525
|
| Exact Mass |
462.198
|
| CAS # |
1494581-70-2
|
| PubChem CID |
91809347
|
| Appearance |
White to off-white solid powder
|
| LogP |
4.7
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
32
|
| Complexity |
809
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
S(NC(C1=C(C=C(C(=C1)C1CC1)OCC12CC3CC(CC(C3)C1)C2)F)=O)(N1CCC1)(=O)=O
|
| InChi Key |
PTCBNPULJWGSML-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)
|
| Chemical Name |
4-(1-adamantylmethoxy)-N-(azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluorobenzamide
|
| Synonyms |
GDC0276; GDC 0276
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~270.22 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (13.51 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1618 mL | 10.8089 mL | 21.6179 mL | |
| 5 mM | 0.4324 mL | 2.1618 mL | 4.3236 mL | |
| 10 mM | 0.2162 mL | 1.0809 mL | 2.1618 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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