| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vitro |
Gibberellic acid can aid in preventing cold stress in chickpea seedlings. Gibberellic acid (10–20 μM) helps seeds retain low electrolyte leakage and high relative water content while also increasing the final emergence probability (FEP) [2]. After treating Echinacea hairy roots with gibberellic acid (0.025 μM), the hairy root cultures' PAL activity, cell survival, and free radical scavenging activity all enhanced. Gibberellic acid promotes the growth of hairy roots and maximizes the generation of secondary metabolites in Echinacea hairy root cultures [3]. br/
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|---|---|
| ln Vivo |
For 25 days, rats were given unlimited access to drinking water containing 75 ppm ABA and GA3. Each rat's PGR intake was roughly 2.2 mg per day [5]. Gibberellic acid (2.2 mg/rat/day; po) can alter the antioxidant system in different rat tissues and increase the amount of lipid peroxides [5].
|
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Translocated /in plants/. |
| Toxicity/Toxicokinetics |
Toxicity Data
LC50 >5,900 mg/m3 |
| References |
|
| Additional Infomation |
Gibberellic acid is a white powder. (NTP, 1992)
Gibberellin A3 is a C19-gibberellin that is a pentacyclic diterpenoid responsible for promoting growth and elongation of cells in plants. Initially identified in Gibberella fujikuroi,it differs from gibberellin A1 in the presence of a double bond between C-3 and C-4. It has a role as a plant metabolite and a mouse metabolite. It is a lactone, a gibberellin monocarboxylic acid, an organic heteropentacyclic compound and a C19-gibberellin. It is a conjugate acid of a gibberellin A3(1-). Gibberellic acid has been reported in Fusarium fujikuroi, Glycine max, and other organisms with data available. Mechanism of Action Gibberellic acid enhanced activity of rat lung guanylate cyclase, an enzyme associated with growth. Gibberellic acid has androgenic activity in chicks. |
| Molecular Formula |
C19H22O6
|
|---|---|
| Molecular Weight |
346.37
|
| Exact Mass |
346.141
|
| CAS # |
77-06-5
|
| Related CAS # |
125-67-7 (mono-potassium salt)
|
| PubChem CID |
6466
|
| Appearance |
Crystals from ethyl acetate
Fine white powder at 23 °C |
| Density |
1.5±0.1 g/cm3
|
| Boiling Point |
628.6±55.0 °C at 760 mmHg
|
| Melting Point |
227 °C
|
| Flash Point |
231.4±25.0 °C
|
| Vapour Pressure |
0.0±4.2 mmHg at 25°C
|
| Index of Refraction |
1.661
|
| LogP |
0.01
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
25
|
| Complexity |
772
|
| Defined Atom Stereocenter Count |
8
|
| SMILES |
O1C([C@]2(C([H])([H])[H])[C@]([H])(C([H])=C([H])[C@]31[C@]2([H])[C@]([H])(C(=O)O[H])[C@]12C([H])([H])C(=C([H])[H])[C@](C([H])([H])C([H])([H])[C@]13[H])(C2([H])[H])O[H])O[H])=O
|
| InChi Key |
IXORZMNAPKEEDV-OBDJNFEBSA-N
|
| InChi Code |
InChI=1S/C19H22O6/c1-9-7-17-8-18(9,24)5-3-10(17)19-6-4-11(20)16(2,15(23)25-19)13(19)12(17)14(21)22/h4,6,10-13,20,24H,1,3,5,7-8H2,2H3,(H,21,22)/t10-,11+,12-,13-,16-,17+,18+,19-/m1/s1
|
| Chemical Name |
(1R,2R,5S,8S,9S,10R,11S,12S)-5,12-dihydroxy-11-methyl-6-methylidene-16-oxo-15-oxapentacyclo[9.3.2.15,8.01,10.02,8]heptadec-13-ene-9-carboxylic acid
|
| Synonyms |
GA; Gibberellin A3; Gibberellic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~288.71 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.01 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.01 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (6.01 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8871 mL | 14.4354 mL | 28.8709 mL | |
| 5 mM | 0.5774 mL | 2.8871 mL | 5.7742 mL | |
| 10 mM | 0.2887 mL | 1.4435 mL | 2.8871 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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