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| ln Vitro |
The contents of amide acetate and active GLP-1(7-36) in the culture medium were significantly greater in the cells treated with phorbol 12-myristate 13-acetate for two hours than in the control group. Additionally, a dose-dependent increase in active GLP-1 production from cells was seen upon glucose administration. GLP-1 is actively secreted by cells in response to dose-dependent stimulation by palmitic acid, oleic acid, linoleic acid, or linolenic acid. Unsaturated fatty acids like oleic, linoleic, and linolenic acid secreted substantially more GLP-1 when active than palmitic acid. The amount of active GLP-1 in the culture media rose dose-dependently when CPE was added to NCI-H716 cells. These cells secreted 37 percent more active GLP-1 at a dose of 0.1% CPE [1].
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| ln Vivo |
Gastric administration of glucose increased active GLP-1(7-36) amide levels in portal blood 10 minutes later, followed by a significant decrease at 30 minutes. When TO was administered gastrically, active GLP-1 levels rose after 10 minutes and fell to basal levels after 60 minutes. Individually, glucose and TO increased GLP-1 secretion in a dose-dependent manner. Furthermore, co-administration of glucose and TO further increased peak GLP-1 levels. Mice given CPE had higher levels of active GLP-1 in portal blood at 10 and 30 minutes compared with control mice. When glucose was administered with CPE, the levels of active GLP-1 and insulin in the portal blood of mice administered CPE were slightly higher than those of control mice. C57BL/6J mice fed a high-fat diet develop hyperglycemia and impaired glucose tolerance [1].
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| References |
[1]. Fujii Y et al. Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1(GLP-1(7-36)) amide in C57BL/6J mice. J Nutr Sci. 2015 Mar 3
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| Molecular Formula |
C149H226N40O45(C2H4O2)N
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|---|---|
| CAS # |
1119517-19-9
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| Related CAS # |
GLP-1(7-36), amide TFA;GLP-1(7-36), amide;107444-51-9
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL
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| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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