| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vitro |
Glycylglutamine, also known as glycyl-L-glutamine, is a neuropeptide that contains glutamine and is both stable and active. When it comes to growth factors for cell culture during autoclaving and storage, glycylglutamine (also known as glycyl-L-glutamine) is superior to free glutamine (Gln) [2].
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|---|---|
| ln Vivo |
Rats anesthetized with pentobarbital are shown to be resistant to β-End-(1-31)-induced hypoxia when given varying doses of glycyl-L-glutamine (0.3, 0.6, 1.0, and 10.0 nM). blood pressure [1].
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| References |
[1]. Unal CB1, et al. Beta-endorphin-induced cardiorespiratory depression is inhibited by glycyl-L-glutamine, a dipeptide derived from beta-endorphin processing.J Pharmacol Exp Ther. 1994 Nov;271(2):952-8
[2]. Roth E, et al. Influence of two glutamine-containing dipeptides on growth of mammalian cells.In Vitro Cell Dev Biol. 1988 Jul;24(7):696-8. |
| Additional Infomation |
Gly-Gln is a dipeptide formed from glycine and L-glutamine residues. It has a role as a metabolite and a protective agent. It is a tautomer of a Gly-Gln zwitterion.
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| Molecular Formula |
C7H13N3O4
|
|---|---|
| Molecular Weight |
203.19
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| Exact Mass |
203.09
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| CAS # |
13115-71-4
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| PubChem CID |
123913
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
643.1±55.0 °C at 760 mmHg
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| Melting Point |
194°C
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| Flash Point |
342.7±31.5 °C
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| Vapour Pressure |
0.0±4.1 mmHg at 25°C
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| Index of Refraction |
1.538
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| LogP |
-2.5
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
14
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| Complexity |
241
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| Defined Atom Stereocenter Count |
1
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| SMILES |
NC(CC[C@H](NC(CN)=O)C(O)=O)=O
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| InChi Key |
PNMUAGGSDZXTHX-BYPYZUCNSA-N
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| InChi Code |
InChI=1S/C7H13N3O4/c8-3-6(12)10-4(7(13)14)1-2-5(9)11/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14)/t4-/m0/s1
|
| Chemical Name |
(2S)-5-amino-2-[(2-aminoacetyl)amino]-5-oxopentanoic acid
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| Synonyms |
L-Glutamine, N2-glycyl-; Gly-gln; Glycylglutamine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~62.5 mg/mL (~307.58 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (492.13 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.9215 mL | 24.6075 mL | 49.2150 mL | |
| 5 mM | 0.9843 mL | 4.9215 mL | 9.8430 mL | |
| 10 mM | 0.4922 mL | 2.4608 mL | 4.9215 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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