Size | Price | Stock | Qty |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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10g |
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Other Sizes |
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Purity: ≥98%
Grape Seed Extract is a natural product isolated from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs. It has a number of health advantages, including an anti-inflammatory effect. The fat-metabolizing enzymes lipoprotein lipase and pancreatic lipase are inhibited by grape seed extract.
ln Vitro |
Grape seed extract (25-100 μg/mL; 12-48 hours) inhibits the growth of and causes the death of human colorectal cancer cells[3].
Grape seed extract (25-100 μg/mL; 12-24 hours) modulates the protein levels of molecules that control the cell cycle in HT29 and LoVo cells[3]. Grape seed extract (25-100 μg/mL; 24 hours) causes human colorectal cancer cells to undergo apoptotic cell death[3]. |
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ln Vivo |
Grape seed extract (200 mg/kg; i.g.; 5 days/wk; for 8 weeks) inhibits the growth of HT29 colon carcinoma tumor xenografts in athymic nude mice[3].
In tumors, grape seed extract decreases cell proliferation while increasing apoptotic cell death[3]. In tumors, grape seed extract increases poly(ADP-ribose) poly-merase cleavage and Cip1/p21 protein levels[3]. |
Animal Protocol |
Athymic male nu/nu mice, with human colon carcinoma HT29 tumor xenograft[3]
200 mg/kg Oral gavage, 5 days/wk, for 8 weeks |
References |
Molecular Formula |
C₃₀H₁₂O₆
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Molecular Weight |
468.42
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CAS # |
84929-27-1
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Related CAS # |
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Appearance |
Solid
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SMILES |
CC1=CC(=C(C2=C1C[C@@]([C@H](O2)C3=CC(=C(C=C3)O)O)(C)O)[C@H]4[C@@H]([C@H](OC5=CC(=CC(=C45)O)O)C6=CC(=C(C=C6)O)O)O)O
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InChi Key |
VWKAFYWVDIOMSL-PMFFMQSYSA-N
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InChi Code |
InChI=1S/C32H30O11/c1-13-7-22(38)26(30-17(13)12-32(2,41)31(43-30)15-4-6-19(35)21(37)9-15)27-25-23(39)10-16(33)11-24(25)42-29(28(27)40)14-3-5-18(34)20(36)8-14/h3-11,27-29,31,33-41H,12H2,1-2H3/t27-,28-,29+,31+,32+/m0/s1
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Chemical Name |
(2R,3S,4S)-2-(3,4-dihydroxyphenyl)-4-[(2R,3R)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-3,5-dimethyl-2,4-dihydrochromen-8-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.6 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 6.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.6 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 6.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.1348 mL | 10.6742 mL | 21.3484 mL | |
5 mM | 0.4270 mL | 2.1348 mL | 4.2697 mL | |
10 mM | 0.2135 mL | 1.0674 mL | 2.1348 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT03087903 | Active Recruiting |
Dietary Supplement: Grape Seed Extract |
Prostate Cancer | University of Colorado, Denver |
January 18, 2018 | Not Applicable |
NCT00713167 | Active Recruiting |
Drug: Grape Seed Extract (Vitagrape) Drug: Placebo of Grape Seed Extract |
Hyperlipidemia | Shahid Beheshti University of Medical Sciences |
July 2008 | Phase 2 Phase 3 |
NCT01185067 | Completed | Drug: grape seed extract | Hypertension Oxidative Stress |
University of Michigan | October 2010 | Phase 1 |
NCT04136639 | Completed | Other: Miswak Other: fluoride |
Dental Caries | Al-Azhar University | June 1, 2019 | Not Applicable |
NCT01820299 | Completed | Drug: Grape Seed Extract Drug: Vitamin D |
Solid Cancers | Medical University of South Carolina |
March 2013 | Phase 1 |