Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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GSK2983559 free acid (compound 3) is a potent, specific and oral bioactive receptor interacting protein 2 (RIP2) kinase inhibitor, showing excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.
Targets |
RIP2 kinase
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ln Vitro |
GSK2983559 was found to be extremely selective in a screen against nonkinase targets (Eurofins, 104 receptor and ion channel binding assays, 35 enzyme and cell-based assays), inhibiting only the melatonin receptor MT3 at a concentration under 10 μM.[1].
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ln Vivo |
GSK2983559 (oral gavage; 3 and 10 mg/kg; once) substantially suppresses MDP-induced IL-6 in mice [2].
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Enzyme Assay |
In a murine 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced colitis model, administration of GSK2983559 at the 7.5 and 145 mg/kg b.i.d doses displays efficacy similar to that of prednisolone as measured by the sum of colon scores.[1].
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Animal Protocol |
Animal/Disease Models: C57BL/6 mice (female) were injected with MDP (100 μg) [2]
Doses: 3 and 10 mg/kg Route of Administration: po (oral gavage); 3 and 10 mg/kg; Experimental Results: in a dose-dependent manner Suppresses serum IL-6 levels. |
References |
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Molecular Formula |
C21H23N4O7PS2
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Molecular Weight |
538.5298
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Exact Mass |
538.074
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Elemental Analysis |
C, 46.84; H, 4.31; N, 10.40; O, 20.80; P, 5.75; S, 11.91
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CAS # |
1579965-12-0
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Related CAS # |
GSK2983559;GSK2983559 active metabolite;1423186-80-4
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PubChem CID |
73386708
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Appearance |
Light yellow to yellow solid powder
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Density |
1.5±0.1 g/cm3
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Boiling Point |
823.6±75.0 °C at 760 mmHg
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Flash Point |
451.9±37.1 °C
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Vapour Pressure |
0.0±3.1 mmHg at 25°C
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Index of Refraction |
1.675
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LogP |
0.55
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Hydrogen Bond Donor Count |
3
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Hydrogen Bond Acceptor Count |
12
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Rotatable Bond Count |
9
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Heavy Atom Count |
35
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Complexity |
878
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Defined Atom Stereocenter Count |
0
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SMILES |
S(C1=CC2=C(N=CN=C2C=C1OCCOP(=O)(O)O)NC1C=CC2=C(C=1)N=CS2)(C(C)(C)C)(=O)=O
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InChi Key |
MJLYDVMFNHZMLV-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C21H23N4O7PS2/c1-21(2,3)35(29,30)19-9-14-15(10-17(19)31-6-7-32-33(26,27)28)22-11-23-20(14)25-13-4-5-18-16(8-13)24-12-34-18/h4-5,8-12H,6-7H2,1-3H3,(H,22,23,25)(H2,26,27,28)
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Chemical Name |
2-[4-(1,3-benzothiazol-5-ylamino)-6-tert-butylsulfonylquinazolin-7-yl]oxyethyl dihydrogen phosphate
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Synonyms |
GSK2983559; GSK-2983559; GSK 2983559; GSK2983559 free acid
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~5 mg/mL (~9.3 mM)
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Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80: Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 :Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.8569 mL | 9.2845 mL | 18.5691 mL | |
5 mM | 0.3714 mL | 1.8569 mL | 3.7138 mL | |
10 mM | 0.1857 mL | 0.9285 mL | 1.8569 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.