| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
GSK467 (0-100 μM; 6 days) exhibits antiproliferative effects on human multiple myeloma tumor cells [1]. The 2-OG binding pocket is located by GSK467 [2]. GSK467 prevents the spheroid and colony formation of HCC cells.
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|---|---|
| ln Vivo |
In female BALB/c nude mice, GSK-467 can suppress the development and proliferation of HCC tumor cells by upregulating the expression of miR-448 and blocking YTHDF3/ITGA6 blue [3].
|
| Cell Assay |
cell proliferation assay [1]
Cell Types: Human multiple myeloma tumor cell line MM.1S Tested Concentrations: 0-100 μM Incubation Duration: 6 days Experimental Results: Demonstrated anti-proliferation Effect, IC50>50 μM. |
| References |
|
| Molecular Formula |
C17H13N5O2
|
|---|---|
| Molecular Weight |
319.317422628403
|
| Exact Mass |
319.106
|
| CAS # |
1628332-52-4
|
| PubChem CID |
135567128
|
| Appearance |
White to off-white solid powder
|
| LogP |
1.5
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
24
|
| Complexity |
491
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O(C1=NC2C=NC=CC=2C(N1)=O)C1C=NN(C=1)CC1C=CC=CC=1
|
| InChi Key |
ZTYRLXUTLYBVHH-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C17H13N5O2/c23-16-14-6-7-18-9-15(14)20-17(21-16)24-13-8-19-22(11-13)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,20,21,23)
|
| Chemical Name |
2-(1-benzylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-one
|
| Synonyms |
GSK 467; GSK-467; GSK467
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~20.83 mg/mL (~65.23 mM)
H2O : < 0.1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.08 mg/mL (6.51 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.08 mg/mL (6.51 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1317 mL | 15.6583 mL | 31.3165 mL | |
| 5 mM | 0.6263 mL | 3.1317 mL | 6.2633 mL | |
| 10 mM | 0.3132 mL | 1.5658 mL | 3.1317 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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