Size | Price | Stock | Qty |
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1mg |
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5mg |
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Other Sizes |
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ln Vitro |
The incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. PKG Iα gatekeeper mutants' kinase activity is inhibited by N6-benzyl-ATP, but WT is not affected. After being released from neuronal exocytosis, serotonin is reabsorbed by the serotonin transporter (SERT). Several mechanisms, including as the cyclic GMP signaling cascade involving PKG, guanylyl cyclase, and nitric oxide synthase, control SERT [1].
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References |
[1]. Wong A, et al. Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. J Biol Chem. 2012 Oct 19;287(43):36051-8
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Molecular Formula |
C35H67N17O11
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Molecular Weight |
902.013780000001
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CAS # |
81187-14-6
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(O)=O)CCC(O)=O)=O)C)=O)CCCNC(=N)N)=O)CO)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCNC(=N)N
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~100 mg/mL (~110.86 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (110.86 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.1086 mL | 5.5432 mL | 11.0864 mL | |
5 mM | 0.2217 mL | 1.1086 mL | 2.2173 mL | |
10 mM | 0.1109 mL | 0.5543 mL | 1.1086 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.