| Size | Price | Stock | Qty |
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Purity: ≥98%
HBX 41108 (HBX-41108) is a novel, potent and selective inhibitor of ubiquitin-specific protease 7 (USP7)with anticancer effects. HBX 41108 inhibits USP7 deubiquitinating activity with an IC(50) in the submicromolar range. HBX 41,108 was shown to affect USP7-mediated p53 deubiquitination in vitro and in cells. As RNA interference-mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.
| References |
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| Molecular Formula |
C13H3CLN4O
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|---|---|
| Molecular Weight |
266.64212
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| Exact Mass |
266
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| Elemental Analysis |
C, 58.56; H, 1.13; Cl, 13.29; N, 21.01; O, 6.00
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| CAS # |
924296-39-9
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| PubChem CID |
16065773
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.66g/cm3
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| Boiling Point |
604.9ºC at 760 mmHg
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| Flash Point |
319.6ºC
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| Index of Refraction |
1.725
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| LogP |
2.084
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
19
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| Complexity |
503
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| Defined Atom Stereocenter Count |
0
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| SMILES |
N#CC1C(C#N)=NC2=C(C(C3C2=CC=C(Cl)C=3)=O)N=1
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| InChi Key |
BIGPXXAUSQLTQR-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
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| Chemical Name |
7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
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| Synonyms |
HBX-41108HBX41108HBX 41,108HBX 41108 HBX-41,108 HBX41,108.
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~937.59 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (3.75 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 + to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7504 mL | 18.7519 mL | 37.5038 mL | |
| 5 mM | 0.7501 mL | 3.7504 mL | 7.5008 mL | |
| 10 mM | 0.3750 mL | 1.8752 mL | 3.7504 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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