| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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Purity: ≥98%
Homosalate is an organic chemical substance used as a UV filter in cosmetics and sunscreens to absorb UVB rays, shielding the skin from sun damage.
| ln Vitro |
Extracellular vesicles (EVs) released by Homosalate-treated cells increase a recipient epithelial tumor cell line's resistance to anchorage loss.[2]
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| Cell Assay |
For EV isolation, 6 × 106 MDA-MB-231 parental cells were seeded per 15 cm culture dish in an ideal number of dishes to produce 70 × 106, 27 × 106 or 50 × 106 secreting cells. After 24 hours, cells were washed once with PBS and then 15 ml of serum- and phenol-red-free Leibovitz's L-15 were added. In phenol-red-free, serum-free Leibovitz's L-15 medium, DMSO (0.1%), Homosalate (10 μM), or Bafilomycin A1 (100 nM) were added before the cells were incubated for 24 or 16 hours, respectively. The following day, cells were counted, and Trypan Blue was used to calculate the percentage of cell viability.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
For local use only, no systemic absorption. For local use only, no systemic absorption. For local use only, no systemic absorption. For local use only, no systemic absorption. Metabolism / Metabolites For local use only, no systemic absorption. Biological Half-Life For local use only, no systemic absorption. |
| Toxicity/Toxicokinetics |
Protein Binding
For local use only, no systemic absorption. |
| References | |
| Additional Infomation |
3,3,5-trimethylcyclohexylsalicylate appears as viscous or light yellow to slightly tan liquid or oil. (NTP, 1992)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester is a benzoate ester and a member of phenols. It is functionally related to a salicylic acid. Homosalate is an organic compound that belongs to salicylates. It is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light. Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer. It is a common ingredient in many commercially available sunscreens. There are no reported adverse effects from homosalate. Homosalate has been reported in Camellia sinensis with data available. See also: Homosalate; OCTINOXATE (component of); Avobenzone; homosalate (component of); Homosalate; Zinc oxide (component of) ... View More ... Drug Indication As ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer. Mechanism of Action Homosalate has the ability to convert incident ultraviolet radiation into less damaging infrared radiation (heat). |
| Molecular Formula |
C16H22O3
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|---|---|
| Molecular Weight |
262.35
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| Exact Mass |
262.156
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| Elemental Analysis |
C, 73.25; H, 8.45; O, 18.30
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| CAS # |
118-56-9
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| Related CAS # |
Homosalate-d4
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| PubChem CID |
8362
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
341.1±15.0 °C at 760 mmHg
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| Flash Point |
132.3±13.2 °C
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| Vapour Pressure |
0.0±0.8 mmHg at 25°C
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| Index of Refraction |
1.539
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| LogP |
5.82
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
19
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| Complexity |
324
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(OC1CC(C)(C)CC(C)C1)C2=CC=CC=C2O
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| InChi Key |
WSSJONWNBBTCMG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3
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| Chemical Name |
(3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate
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| Synonyms |
Homomenthyl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~381.2 mM; Need ultrasonic)
H2O: <0.1 mg/mL (insoluble) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.53 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (9.53 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.53 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8117 mL | 19.0585 mL | 38.1170 mL | |
| 5 mM | 0.7623 mL | 3.8117 mL | 7.6234 mL | |
| 10 mM | 0.3812 mL | 1.9059 mL | 3.8117 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT03582215 | Completed | Drug: Part 1: Cream Drug: Part 1: Lotion |
Systemic Exposure to Sunscreen Ingredients |
Food and Drug Administration (FDA) |
July 18, 2018 | Phase 1 |
| NCT01001975 | Completed | Drug: Sunscreen Test Code: V53-028 Drug: Sunscreen Test Code: V53-030 |
Sun Protection | Bayer | July 2009 | Phase 3 |
| NCT00530387 | Completed | Drug: 19 organic sunscreen filters and 5 topical NSAIDs |
Dermatitis, Photocontact | NHS Tayside | July 2008 |
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