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| 25mg |
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| 50mg |
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| 100mg |
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Purity: ≥98%
HQNO, secreted by P. aeruginosa, is a novel and potent electron transport chain inhibitor with a Kd of 64 nM for complex III. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species.
| ln Vitro |
HQNO is effective in reducing free radicals that are highly reactive for mitochondrial type II NADH:quinone oxidase (NDH-2) in a variety of species, such as Staphylococcus aureus, Saccharomyces cerevisiae, Gluconobacter oxidans, Toxoplasma gondii, Yarrowia lipolytica, and Plasmodium falciparum. For wild-type (WT) and I379E C, the range of HQNO concentrations was 0 to 100 μM and 0 to 300 μM, respectively. thermarum NDH-2 variations, in accordance with IC50 values. WT NDH-2's IC50 value in the presence of 400μM methoquinone (MD) is 10.5±1.3μM HQNO. The IC50 value of HQNO reduced to 7.3±1.2 μM in the presence of 50 μM MD, while >50 μM HQNO resulted in near total suppression (~15% residual activity). HQNO inhibition was measured at 50μM MD, and the IC50 value was 54.3±1.2μM[2].
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| References |
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| Additional Infomation |
2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a monohydroxyquinoline and a quinoline N-oxide.
2-Heptyl-4-hydroxyquinoline n-oxide has been reported in Streptomyces with data available. |
| Molecular Formula |
C16H21NO2
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|---|---|
| Molecular Weight |
259.34344
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| Exact Mass |
259.157
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| CAS # |
341-88-8
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| PubChem CID |
1561
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
445.8±37.0 °C at 760 mmHg
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| Melting Point |
156-157ºC
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| Flash Point |
223.4±26.5 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.558
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| LogP |
3.18
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
19
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| Complexity |
338
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ICTVCUOZYWNYHM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H21NO2/c1-2-3-4-5-6-9-13-12-16(18)14-10-7-8-11-15(14)17(13)19/h7-8,10-12,19H,2-6,9H2,1H3
|
| Chemical Name |
2-heptyl-1-hydroxyquinolin-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~5 mg/mL (~19.28 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 0.5 mg/mL (1.93 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.5 mg/mL (1.93 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8559 mL | 19.2797 mL | 38.5594 mL | |
| 5 mM | 0.7712 mL | 3.8559 mL | 7.7119 mL | |
| 10 mM | 0.3856 mL | 1.9280 mL | 3.8559 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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