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Cipepofol (HSK3486; HSK3486) is a novel and potent general anesthetic and a close analog of propofol. HSK3486 is now in advanced phase II clinical trial in China. HSK3486 has therapeutic potentials for insomnia, migraine, anxiety, analgesia, etc.
| References | |
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| Additional Infomation |
HSK-3486 is under investigation in clinical trial NCT04620031 (A Study Evaluating Sedation of Intravenous Administration of HSK3486 Injectable Emulsion in ICU Patients Undergoing Mechanical Ventilation).
Cipepofol is a 2,6-disubstituted alkylphenol and structural analog of propofol, that may potentially be used for the induction of sedation and hypnosis during general anesthesia. Upon intravenous administration, cipepofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA). This induces and maintains sedation and hypnosis. |
| Molecular Formula |
C14H20O
|
|---|---|
| Molecular Weight |
204.308
|
| Exact Mass |
204.151
|
| CAS # |
1637741-58-2
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| Related CAS # |
(S)-Cipepofol;1637741-59-3;Cipepofol-d6;2677052-88-7;Cipepofol-d6-2;2677052-87-6
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| PubChem CID |
86301664
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| Appearance |
Colorless to light yellow liquid
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| LogP |
4.4
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
15
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| Complexity |
207
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C[C@H](C1CC1)C2=CC=CC(=C2O)C(C)C
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| InChi Key |
BMEARIQHWSVDBS-SNVBAGLBSA-N
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| InChi Code |
InChI=1S/C14H20O/c1-9(2)12-5-4-6-13(14(12)15)10(3)11-7-8-11/h4-6,9-11,15H,7-8H2,1-3H3/t10-/m1/s1
|
| Chemical Name |
2-[(1R)-1-cyclopropylethyl]-6-propan-2-ylphenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~489.45 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.24 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.24 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.24 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8945 mL | 24.4726 mL | 48.9452 mL | |
| 5 mM | 0.9789 mL | 4.8945 mL | 9.7890 mL | |
| 10 mM | 0.4895 mL | 2.4473 mL | 4.8945 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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