Size | Price | Stock | Qty |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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10g |
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Other Sizes |
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Purity: ≥98%
Hydroxychloroquine sulfate (Hydrochloroquine) has been reported to be highly effective in fighting against SARS-CoV-2 (COVID-19, CoronaVirus) infections, the COVID-19 pandemic. It is a synthetic analog of quinolyl with chemotherapeutic and antibiotic properties. Hydroxychloroquine Sulfate acts against erythrocytic malarial parasites by inhibiting plasmodial heme polymerase and through other unknown mechanisms. Hydroxychloroquine also has anti-inflammatory properties and is used in the treatment of rheumatoid arthritis and lupus erythematosus.
ln Vitro |
For many years, certain types of rheumatoid arthritis, including rheumatoid arthritis (RA), have been treated with hydroxychloroquine sulfate, a synthetic antimalarial medication developed from a 4-quinoline derivative [1]. While these dosages can block DNA or RNA ligand-induced TLR9 or 7 signaling, or chloroquine likewise has no discernible effect on intracellular pH [2].
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ln Vivo |
The sulfuric acid stock market Quexian and its counterparts, the sulfuric acid stock market Quexian mean retracement TLR7 and 9 signals, are used to treat lupus [2].
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References |
[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.
[2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237 |
Molecular Formula |
C18H28CLN3O5S
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Molecular Weight |
433.948
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CAS # |
747-36-4
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Related CAS # |
Hydroxychloroquine;118-42-3;(S)-Hydroxychloroquine;137433-24-0;(R)-Hydroxychloroquine;137433-23-9;Hydroxychloroquine sulfate (Standard);747-36-4;Hydroxychloroquine-d4 sulfate;1854126-45-6
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
CCN(CCO)CCCC(NC1=CC=NC2=CC(Cl)=CC=C12)C.O=S(O)(O)=O
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InChi Key |
JCBIVZZPXRZKTI-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)181-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)(H2,1,2,3,4)
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Chemical Name |
2-((4-((7-chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethan-1-ol sulfate
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Synonyms |
Ercoquin Plaquinol Toremonil Oxychlorochin Oxychloroquine Plaquenil
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~110 mg/mL (~253.49 mM)
DMF : 1.4 mg/mL (~3.23 mM) DMSO :< 1 mg/mL |
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (230.44 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.3044 mL | 11.5221 mL | 23.0441 mL | |
5 mM | 0.4609 mL | 2.3044 mL | 4.6088 mL | |
10 mM | 0.2304 mL | 1.1522 mL | 2.3044 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.