| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
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| ln Vitro |
The resultant nanohybrid proved suited for application in aqueous solutions because hydroxyethyl cellulose was utilized to stabilize graphene oxide in physiological fluids. Graphene oxide can be efficiently stabilized in solution by hydroxyethyl cellulose, and the stabilization mechanism appears to be dependent on the amount of hydroxyethyl cellulose present. The hybrid's hydroxyethylcellulose content is crucial to the end use, serving as either the main drug carrier for folic acid or a vehicle for controlled drug release [1]. During the freeze-thaw process, hydroxyethylcellulose demonstrates remarkable cryoprotection against lactose diphosphate (LDH) and significant freeze-drying protection. There is not much of an impact of freezing on hydroxyethylcellulose stability. Tween 80, a surfactant, can be added to the formulation prior to freeze-drying in order to significantly increase the longer reconstitution time of hydroxyethylcellulose cellulose lyophilisate [2].
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| References |
[1]. Mianehrow H, et al. Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application. Int J Pharm. 2015 Apr 30;484(1-2):276-82.
[2]. Al-Hussein A, et al. Investigation of the stabilizing effects of hydroxyethyl cellulose on LDH during freeze drying and freeze thawing cycles. Pharm Dev Technol. 2015 Jan;20(1):50-9. |
| Molecular Formula |
C29H52O21
|
|---|---|
| Molecular Weight |
736.7106
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| CAS # |
9004-62-0
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| Related CAS # |
Cellulose;9004-34-6;CM Cellulose CM-32;9000-11-7
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
O1C([H])(C([H])(C([H])(C([H])(C1([H])C([H])([H])OC1([H])C([H])(C([H])(C([H])(C([H])(C([H])([H])O[H])O1)OC([H])([H])[H])O[H])O[H])OC1([H])C([H])(C([H])(C([H])(C([H])(C([H])([H])O[H])O1)OC([H])([H])[H])O[H])OC([H])([H])C([H])([H])O[H])O[H])O[H])OC1([H])C([H])(C([H])([H])O[H])OC([H])(C([H])([H])[H])C([H])(C1([H])O[H])O[H]
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~9.09 mg/mL
DMSO : ~1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3574 mL | 6.7869 mL | 13.5739 mL | |
| 5 mM | 0.2715 mL | 1.3574 mL | 2.7148 mL | |
| 10 mM | 0.1357 mL | 0.6787 mL | 1.3574 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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