| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
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| ln Vitro |
The resultant nanohybrid proved suited for application in aqueous solutions because hydroxyethyl cellulose was utilized to stabilize graphene oxide in physiological fluids. Graphene oxide can be efficiently stabilized in solution by hydroxyethyl cellulose, and the stabilization mechanism appears to be dependent on the amount of hydroxyethyl cellulose present. The hybrid's hydroxyethylcellulose content is crucial to the end use, serving as either the main drug carrier for folic acid or a vehicle for controlled drug release [1]. During the freeze-thaw process, hydroxyethylcellulose demonstrates remarkable cryoprotection against lactose diphosphate (LDH) and significant freeze-drying protection. There is not much of an impact of freezing on hydroxyethylcellulose stability. Tween 80, a surfactant, can be added to the formulation prior to freeze-drying in order to significantly increase the longer reconstitution time of hydroxyethylcellulose cellulose lyophilisate [2].
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| References |
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| Additional Infomation |
Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic character.
Drug Indication For alleviating surface irritation in topical ocular administrations, such as artificial tear solutions. Hydroxyethyl cellulose is also found in topical formulations to aid in more efficient drug diffusion across the membranes. Mechanism of Action Interacts with the solid surface through hydrogen bonding to thicken and prolong the formation time of a water-retaining film. Hydroxyethyl cellulose acts as a drug carrier or microsphere to entrap other drug molecules and form a viscous gel-like dispersion, enabling drug diffusion across biological membranes. Pharmacodynamics Hydroxyethyl cellulose acts as a demulcent by relieving inflammation or irritation and dryness of eyes. It acts as one of the key ingredient and viscosity-enhancing agent to prolong corneal contact time and increase intraocular drug levels. |
| Molecular Formula |
C29H52O21
|
|---|---|
| Molecular Weight |
736.7106
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| Exact Mass |
154.012
|
| CAS # |
9004-62-0
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| Related CAS # |
Cellulose;9004-34-6;CM Cellulose CM-32;9000-11-7
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| PubChem CID |
24846132
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| Appearance |
White to off-white solid powder
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| Density |
0.75 g/mL at 25ºC(lit.)
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| Melting Point |
288-290ºC (dec.)
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| LogP |
0.352
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| Hydrogen Bond Donor Count |
11
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| Hydrogen Bond Acceptor Count |
21
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
50
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| Complexity |
999
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
CWSZBVAUYPTXTG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C29H52O21/c1-10-15(34)16(35)24(13(8-33)45-10)49-28-20(39)18(37)25(50-29-26(43-5-4-30)21(40)23(42-3)12(7-32)47-29)14(48-28)9-44-27-19(38)17(36)22(41-2)11(6-31)46-27/h10-40H,4-9H2,1-3H3
|
| Chemical Name |
5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~9.09 mg/mL
DMSO : ~1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3574 mL | 6.7869 mL | 13.5739 mL | |
| 5 mM | 0.2715 mL | 1.3574 mL | 2.7148 mL | |
| 10 mM | 0.1357 mL | 0.6787 mL | 1.3574 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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