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| 5g |
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| Other Sizes |
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| ln Vitro |
Ipriflavone decreases the proliferation and DNA synthesis of MDA-231 cells and suppresses ligand-induced EGFR Tyr(845) phosphorylation. Yipflavone does not increase apoptosis of MDA-231 cells [1]. Isopreflavone can also stimulate calcium deposition and the production of mineralized nodules in newborn rat skull osteoblast-like cells as well as alkaline phosphatase activity [2].
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| ln Vivo |
Daily oral administration of ipriflavone 12 mg/mouse can greatly suppress the emergence of new osteolytic bone metastases and the progression of established osteolytic lesions, consequently increasing the longevity of tumor-bearing mice. Isoflavone lowers the number of osteoclasts at the bone-cancer interface without substantial negative effects on the host [1]. One month of isoflavone therapy increases bone density and improves biomechanical qualities of adult rat male bones without affecting mineral composition[3]
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| ADME/Pharmacokinetics |
Metabolism / Metabolites
Ipriflavone has known human metabolites that include 3-Phenyl-7-(1-methyl-2-hydroxyethoxy)-4H-1-benzopyran-4-one, 7-Hydroxyisoflavone, and 4H-1-Benzopyran-4-one, 3-(4-hydroxyphenyl)-7-(1-methylethoxy)-. |
| References |
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| Additional Infomation |
Ipriflavone is a member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women. It has a role as a bone density conservation agent. It is a member of isoflavones and an aromatic ether.
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| Molecular Formula |
C18H16O3
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|---|---|
| Molecular Weight |
280.323
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| Exact Mass |
280.109
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| CAS # |
35212-22-7
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| PubChem CID |
3747
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
435.9±45.0 °C at 760 mmHg
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| Melting Point |
116-120 °C(lit.)
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| Flash Point |
209.3±15.1 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.592
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| LogP |
4.37
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
21
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| Complexity |
407
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C1C(C2=CC=CC=C2)=COC3=CC(OC(C)C)=CC=C13
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| InChi Key |
SFBODOKJTYAUCM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3
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| Chemical Name |
3-phenyl-7-propan-2-yloxychromen-4-one
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| Synonyms |
FL 113; FL-113; Ipriflavone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~33.33 mg/mL (~118.90 mM)
H2O : < 0.1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.92 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5674 mL | 17.8368 mL | 35.6735 mL | |
| 5 mM | 0.7135 mL | 3.5674 mL | 7.1347 mL | |
| 10 mM | 0.3567 mL | 1.7837 mL | 3.5674 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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