| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
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Purity: ≥98%
Isoimperatorin is a COX-2 inhibitor. It induces cell cycle arrest and inhibits proliferation in melanoma cells, prevents activation of carcinogens, increases expression of PPAR-γ, and suppresses degranulation of bone marrow-derived mast cells.
| ln Vitro |
The ethanol extract of Rhizoctonia rhizome was discovered to have substantial nematicidal action against two nematodes, namely the southern root-knot nematode and the pine wood nematode, during the screening process of novel agrochemicals derived from traditional Chinese medicinal ingredients. Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin were the four components of the ethanol extract that were separated based on bioactivity-guided fractionation. Isomperatorin's LC50 value against the pine wood nematode is 21.83 μg/mL. While columbianetin was just twice as harmful as the dark treatment, falcarindiol, falcarinol, and isoimperatorin were nearly five times more poisonous to Meloidogyne incognita after being exposed to a 15-minute UV light therapy. It has been demonstrated that isoimperatorin exhibits insecticidal activity against a range of insects, including cabbage aphids (Brevicoryne bassicae) [2]. The active component of the extract from Angelica dahurica dahurica (AD) included isoimperatorin [3]. An internal standard (IS) that is frequently utilized is isoimperatorin [4].
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| References |
[1]. Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25(6):856-9.
[2]. Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21(10). pii: E1276. [3]. Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11(7):e0158796. [4]. Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62. |
| Molecular Formula |
C16H14O4
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|---|---|
| Molecular Weight |
270.2800
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| CAS # |
482-45-1
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| Related CAS # |
Isoimperatorin-d6
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
O(C([H])([H])/C(/[H])=C(\C([H])([H])[H])/C([H])([H])[H])C1=C2C([H])=C([H])C(=O)OC2=C([H])C2=C1C([H])=C([H])O2
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Ethanol : ~8.33 mg/mL (~30.82 mM)
DMSO : ~2.5 mg/mL (~9.25 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.83 mg/mL (3.07 mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear EtOH stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.83 mg/mL (3.07 mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear EtOH stock solution to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6999 mL | 18.4993 mL | 36.9987 mL | |
| 5 mM | 0.7400 mL | 3.6999 mL | 7.3997 mL | |
| 10 mM | 0.3700 mL | 1.8499 mL | 3.6999 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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