Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
JNJ-7777120 (JNJ7777120; JNJ 7777120), an indole analog, is a potent and selective non-imidazole-based histamine H4R receptor antagonist that can reduce allergic and asthmatic symptoms. It suppresses the histamine H4R receptor with a Ki of 4 ±1 nM. JNJ-7777120 was found by Johnson & Johnson Pharmaceuticals using an HTS/high throughput screen.
Targets |
Histamine H4 receptor ( Ki = 4.5 nM )
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ln Vitro |
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ln Vivo |
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Enzyme Assay |
JNJ-7777120 is a highly selective H4R antagonist that shows >1000-fold selectivity over other histamin receptors, with a Ki of 4 ±1 nM.
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Cell Assay |
JNJ-7777120 inhibits the migration of lung fibroblasts induced by fibronectin, indicating that H4R may be a promising target for the creation of novel medications intended to treat lung fibrosis.
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Animal Protocol |
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References |
Molecular Formula |
C14H16CLN3O
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Molecular Weight |
277.75
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Exact Mass |
277.1
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Elemental Analysis |
C, 60.54; H, 5.81; Cl, 12.76; N, 15.13; O, 5.76
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CAS # |
459168-41-3
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Related CAS # |
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Appearance |
Solid powder
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SMILES |
CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Cl
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InChi Key |
HUQJRYMLJBBEDO-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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Chemical Name |
(5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.00 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.00 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.00 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 30% Propylene glycol , 5% Tween 80 , 65% D5W: 20 mg/mL |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.6004 mL | 18.0018 mL | 36.0036 mL | |
5 mM | 0.7201 mL | 3.6004 mL | 7.2007 mL | |
10 mM | 0.3600 mL | 1.8002 mL | 3.6004 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.