| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
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| Targets |
PDK1 (IC50 = 49 nM); PDK2 (IC50= 101 nM); PDK3 (IC50= 313 nM)
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|---|---|
| ln Vitro |
JX06 barely shows inhibitory activity against PDK4 at a concentration of 10 μM[1].
JX06 (1-10 μM; 48 hours) induces cell apoptosis in cancer cells with high ECAR/OCR[1].JX06(0-0.6 μM; 72 hours) inhibits the growth of A549 cells in a dose-dependent manner[1]. JX06(0.1-10 μM; 6-24 hours) inhibits PDHA1 phosphorylation in A549 cells in a time- and dose-dependent manner.[1] JX06 (1–10 μM) increases intracellular ATP levels and glucose uptake while decreasing aerobic glycolysis as measured by lactate production in A549 cells[1]. JX06 (1-10 μM; 24 hours) induces ROS generation in cancer cells with high extracellular acidification rate (ECAR)/ oxygen consumption rate (OCR) [1].
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| ln Vivo |
JX06 (40-80 mg/kg; i.p. for 21 days) inhibits tumor growth in vivo[1].
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| Animal Protocol |
A549 subcutaneous xenograft mice[1]
40, 80 mg/kg I.p. injections for 21 days |
| References |
| Molecular Formula |
C10H16N2O2S4
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|---|---|
| Molecular Weight |
324.49
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| Exact Mass |
324.009
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| Elemental Analysis |
C, 37.02; H, 4.97; N, 8.63; O, 9.86; S, 39.52
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| CAS # |
729-46-4
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| Related CAS # |
729-46-4
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| PubChem CID |
12892
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| Appearance |
White to off-white solid powder
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| Density |
1.463g/cm3
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| Boiling Point |
466.3ºC at 760 mmHg
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| Flash Point |
235.8ºC
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| Index of Refraction |
1.69
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| LogP |
1.477
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
18
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| Complexity |
274
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1COCCN1C(=S)SSC(=S)N2CCOCC2
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| InChi Key |
KKVYOWPPMNSLCP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H16N2O2S4/c15-9(11-1-5-13-6-2-11)17-18-10(16)12-3-7-14-8-4-12/h1-8H2
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| Chemical Name |
morpholine-4-carbothioylsulfanyl morpholine-4-carbodithioate
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| Synonyms |
JX06 JX 06 JX-06
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 50~65 mg/mL (154.1~200.3 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.70 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (7.70 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.70 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0818 mL | 15.4088 mL | 30.8176 mL | |
| 5 mM | 0.6164 mL | 3.0818 mL | 6.1635 mL | |
| 10 mM | 0.3082 mL | 1.5409 mL | 3.0818 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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