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100mg | ||
250mg | ||
500mg |
ln Vitro |
L-tyrosine does not change malate dehydrogenase in the hippocampal (1.0-4.0 mM) or posterior cortex (0.1-4.0 mM), and it suppresses citrate synthase activity in the latter two regions (2.0 and 4.0 mM). elevated levels of striatum (4.0 mM), liver (0.1-4.0 mM), and succinate dehydrogenase. Analysis of complex I activity revealed suppression in the hippocampal region (4.0 mM). Complex II has inhibitory effects not just in the hippocampus but also in the liver (1.0, 2.0, and 4.0 mM) and posterior cortex (0.1-4.0 mM). L-tyrosine administration results in decreased activity of complex IV in the posterior brain (1.0-4.0 mM) and no change in the activity of complexes II–III[1].
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ln Vivo |
L-tyrosine administered acutely reduced the activity of citrate synthase in the liver and posterior cortex but enhanced it in the striatum. The findings also shown that in the rat liver and posterior cortex, acute treatment of L-Tyrosine decreased the activity of complexes II, III, and IV of the mitochondrial respiratory chain and malate dehydrogenase. The striatum showed an increase in complex I and succinate dehydrogenase activity, while the posterior cortex showed an inhibition. Moreover, acute L-tyrosine treatment does not change the hippocampal energy metabolism [1].
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References |
[1]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35
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Molecular Formula |
C9H11NO3
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Molecular Weight |
181.1885
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CAS # |
60-18-4
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
O([H])C([C@]([H])(C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])O[H])N([H])[H])=O
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
1M HCl : 50 mg/mL (~275.95 mM)
DMSO : ~1 mg/mL (~5.52 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: 40 mg/mL (220.76 mM) in 50% PEG300 + 50% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication (<60°C).
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 40 mg/mL (220.76 mM) in 0.5% CMC-Na/saline water (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.5191 mL | 27.5953 mL | 55.1907 mL | |
5 mM | 1.1038 mL | 5.5191 mL | 11.0381 mL | |
10 mM | 0.5519 mL | 2.7595 mL | 5.5191 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.