| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
L002 also exhibits a weak inhibitory effect on a group of p300s with Manhattan on additional cardiac transferases, decyclases, and methyltransferases, as well as PCAF and GCN5 (IC50=35 and 34 μM) [1].
|
|---|---|
| ln Vivo |
L002, an intraperitoneal injection administered every three days for two weeks at a dose of 20 μg/gm body weight, is used to treat hypertensive cardiac hypertrophy and fibrosis. It also has the ability to significantly reverse these conditions. In comparison to treatment, it also lowers the amounts of interstitial and perivascular collagen in the heart [3].
|
| Animal Protocol |
Animal/Disease Models: Wild-type C57BL/6 male mice were implanted with a mini-osmotic pump (angiotensin II 1500 ng/kg/min) for 4 weeks [3]
Doses: 20 μg/g body weight; once every three days; given every 2 weeks Drug: intraperitoneal (ip) injection Experimental Results: reversed cardiac fibrosis in mice caused by hypertension. |
| References |
|
| Molecular Formula |
C15H15NO5S
|
|---|---|
| Molecular Weight |
321.348303079605
|
| Exact Mass |
321.067
|
| CAS # |
321695-57-2
|
| PubChem CID |
2221149
|
| Appearance |
Light yellow to yellow solid powder
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
459.8±55.0 °C at 760 mmHg
|
| Flash Point |
231.9±31.5 °C
|
| Vapour Pressure |
0.0±1.1 mmHg at 25°C
|
| Index of Refraction |
1.574
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| LogP |
4.06
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| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
4
|
| Heavy Atom Count |
22
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| Complexity |
607
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
VEWFTYOFWIXCIO-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C15H15NO5S/c1-10-8-12(9-11(2)15(10)17)16-21-22(18,19)14-6-4-13(20-3)5-7-14/h4-9H,1-3H3
|
| Chemical Name |
[(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] 4-methoxybenzenesulfonate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~311.19 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.47 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1119 mL | 15.5594 mL | 31.1187 mL | |
| 5 mM | 0.6224 mL | 3.1119 mL | 6.2237 mL | |
| 10 mM | 0.3112 mL | 1.5559 mL | 3.1119 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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