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LEP(116-130)(mouse)

Cat No.:V31171 Purity: ≥98%
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
LEP(116-130)(mouse)
LEP(116-130)(mouse) Chemical Structure CAS No.: 258276-95-8
Product category: New2
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
1mg
5mg
10mg
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Product Description
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
Biological Activity I Assay Protocols (From Reference)
ln Vitro
LEP-(116-130) (300 µM) does not reduce AP-OB binding [1].
ln Vivo
Compared to vehicle-injected control mice, LEP-(116–130) (1 mg, i.p.) produced a lower rate of weight gain during periods of high food intake. Blood glucose levels can be markedly lowered by LEP-(116–130) by about 100 mg/dL. The capacity of wild-type (+/+) C57BLKS/Jm mice to regulate their body temperature was unaffected by the administration of LEP-(116–130) for four or seven days [1].
References
[1]. Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. 1999 Nov;48(11):2204-9
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C64H109N19O24S
Molecular Weight
1560.72816
Exact Mass
1559.76
CAS #
258276-95-8
PubChem CID
90471193
Appearance
Typically exists as solid at room temperature
LogP
-12.3
Hydrogen Bond Donor Count
24
Hydrogen Bond Acceptor Count
27
Rotatable Bond Count
50
Heavy Atom Count
108
Complexity
3150
Defined Atom Stereocenter Count
15
SMILES
CC(C[C@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CO)=O)CS)=O)CO)=O)CC(C)C)=O)=O)CCC(N)=O)=O)[C@H](O)C)=O)CO)=O)=O)C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CCC(O)=O)=O)=O)CCCCN)=O)CCC(N)=O)=O)C
InChi Key
YEHDWBRMEXDYLT-RDEOYNLOSA-N
InChi Code
InChI=1S/C64H109N19O24S/c1-30(2)22-38(57(100)72-34(13-16-46(67)89)54(97)75-37(10-6-7-19-65)63(106)82-20-8-11-44(82)60(103)74-36(15-18-49(92)93)55(98)77-40(26-85)51(69)94)71-48(91)24-70-53(96)41(27-86)79-62(105)50(32(5)88)81-56(99)35(14-17-47(68)90)73-61(104)45-12-9-21-83(45)64(107)39(23-31(3)4)76-58(101)42(28-87)78-59(102)43(29-108)80-52(95)33(66)25-84/h30-45,50,84-88,108H,6-29,65-66H2,1-5H3,(H2,67,89)(H2,68,90)(H2,69,94)(H,70,96)(H,71,91)(H,72,100)(H,73,104)(H,74,103)(H,75,97)(H,76,101)(H,77,98)(H,78,102)(H,79,105)(H,80,95)(H,81,99)(H,92,93)/t32-,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,50+/m1/s1
Chemical Name
(4S)-4-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
H2O : ~50 mg/mL (~32.04 mM)
Solubility (In Vivo)
Solubility in Formulation 1: 100 mg/mL (64.07 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.

 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 0.6407 mL 3.2036 mL 6.4073 mL
5 mM 0.1281 mL 0.6407 mL 1.2815 mL
10 mM 0.0641 mL 0.3204 mL 0.6407 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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In vivo Formulation Calculator (Clear solution)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

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