| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
|
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| 500mg |
|
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| 1g |
|
| ln Vivo |
In this chronic mouse asthma model, L-carnitine hydrochloride ((R)-Carnitine hydrochloride) (125, 250 mg/kg; ip) had more substantial bronchodilation and lower urinary LTE4 excretion [2].
|
|---|---|
| Animal Protocol |
Animal/Disease Models: 8- to 10-weeks-old and weighed 28-30g balb/c (Bagg ALBino) mouse[2]
Doses: 125, 250 mg/kg Route of Administration: ip Experimental Results: SaO2 increased Dramatically at 250 mg/kg and diminished urinaryLTE4 excretion. |
| References |
| Molecular Formula |
C7H16CLNO3
|
|---|---|
| Molecular Weight |
197.65
|
| Exact Mass |
197.081
|
| CAS # |
6645-46-1
|
| PubChem CID |
656657
|
| Appearance |
White to off-white solid powder
|
| Melting Point |
142 °C
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
12
|
| Complexity |
139
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C[N+](C)(C)C[C@@H](CC(=O)O)O.[Cl-]
|
| InChi Key |
JXXCENBLGFBQJM-FYZOBXCZSA-N
|
| InChi Code |
InChI=1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m1./s1
|
| Chemical Name |
[(2R)-3-carboxy-2-hydroxypropyl]-trimethylazanium;chloride
|
| Synonyms |
L-Carnitine chloride; (R)-Carnitine hydrochloride; Levocarnitine chloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~250 mg/mL (~1264.80 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (252.96 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0594 mL | 25.2972 mL | 50.5945 mL | |
| 5 mM | 1.0119 mL | 5.0594 mL | 10.1189 mL | |
| 10 mM | 0.5059 mL | 2.5297 mL | 5.0594 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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