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Purity: ≥98%
Levofloxacin Hemihydrate [(-)-Ofloxacin], a synthetic fluoroquinolone, is a broad-spectrum and third-generation fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levofloxacin is used to treat various bacterial infections including respiratory, urinary tract, gastrointestinal, and abdominal infections. Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate activity against anaerobes.
Targets |
TOPO IV
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References |
Molecular Formula |
C36H42F2N6O9
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Molecular Weight |
740.76
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Exact Mass |
740.2981
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Elemental Analysis |
C, 58.37; H, 5.72; F, 5.13; N, 11.35; O, 19.44
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CAS # |
138199-71-0
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Related CAS # |
Levofloxacin;100986-85-4;Levofloxacin hydrochloride;177325-13-2;(R)-Ofloxacin;100986-86-5
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Appearance |
Solid powder
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SMILES |
O=C(C1=CN2C3=C(C=C(F)C(N4CCN(C)CC4)=C3OC[C@@H]2C)C1=O)O.[H]O[H].O=C(C5=CN6C7=C(C=C(F)C(N8CCN(C)CC8)=C7OC[C@@H]6C)C5=O)O
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InChi Key |
SUIQUYDRLGGZOL-RCWTXCDDSA-N
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InChi Code |
InChI=1S/2C18H20FN3O4.H2O/c2*1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h2*7-8,10H,3-6,9H2,1-2H3,(H,24,25);1H2/t2*10-;/m00./s1
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Chemical Name |
(S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hemihydrate
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Synonyms |
RWJ 25213; RWJ-25213; RWJ25213; Levofloxacin Hydrate; Levofloxacin Hemihydrate
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HS Tariff Code |
2934.99.03.00
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ≥ 50 mg/mL (~135.00 mM)
Ethanol : ~10 mg/mL DMSO : ~8.33 mg/mL (~22.49 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.83 mg/mL (2.24 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.83 mg/mL (2.24 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 0.83 mg/mL (2.24 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 0.83 mg/mL (2.24 mM) Solubility in Formulation 5: 100 mg/mL (269.99 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.3500 mL | 6.7498 mL | 13.4996 mL | |
5 mM | 0.2700 mL | 1.3500 mL | 2.6999 mL | |
10 mM | 0.1350 mL | 0.6750 mL | 1.3500 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.