| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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Purity: ≥98%
| Targets |
VEGFR-3; Akt; GSK3β; RhoA
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|---|---|
| ln Vitro |
MAZ51 (2.5-10 μM; 24 hours) causes apoptosis and inhibits the growth of many different types of tumor cells[2].
MAZ51 (0.5-50 μM; 25 minutes) does not affect the ligand-induced autophosphorylation of PDGFRβ, IGF-1R, or EGFR in A431 cells, HEK-293 cells, or PAE cells, respectively[2].
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| ln Vivo |
MAZ51 (8 mg/kg; i.p.; daily for 15 day) tumor growth is significantly suppressed by MAZ51[2].
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| Animal Protocol |
Wistar Furth rats (bearing MT450 cells)[1]
8 mg/kg Intraperitoneal injection; daily for 15 day |
| References |
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| Additional Infomation |
3-[[4-(dimethylamino)-1-naphthalenyl]methylidene]-1H-indol-2-one is a member of naphthalenes.
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| Molecular Formula |
C₂₁H₁₈N₂O
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|---|---|
| Molecular Weight |
314.38
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| Exact Mass |
314.141
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| CAS # |
163655-37-6
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| Related CAS # |
163655-37-6
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| PubChem CID |
9839842
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| Appearance |
Orange to red solid
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
553.9±50.0 °C at 760 mmHg
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| Flash Point |
288.8±30.1 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
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| Index of Refraction |
1.729
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| LogP |
5.15
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
24
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| Complexity |
512
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CN(C1=CC=C(C2=CC=CC=C21)/C=C/3\C4=CC=CC=C4NC3=O)C
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| InChi Key |
VFCXONOPGCDDBQ-QGOAFFKASA-N
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| InChi Code |
InChI=1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)/b18-13+
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| Chemical Name |
(3E)-3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one
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| Synonyms |
MAZ51; MAZ-51; MAZ 51
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product is not stable in solution, please use freshly prepared working solution for optimal results. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 11.4~63 mg/mL (36.1~200.4 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.83 mg/mL (2.64 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: 4 mg/mL (12.72 mM) in 50% PEG300 50% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1809 mL | 15.9043 mL | 31.8086 mL | |
| 5 mM | 0.6362 mL | 3.1809 mL | 6.3617 mL | |
| 10 mM | 0.3181 mL | 1.5904 mL | 3.1809 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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