| Size | Price | Stock | Qty |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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Purity: ≥98%
Methyl-5-aminolevulinate HCl, a prodrug that is metabolised to Protoporphyrin IX (sensitizer) used in photodynamic therapy, is a used as a topical cream formulation which contains the hydrochloride salt of methyl-5-aminolevulinate, a lipophilic methyl ester of 5-aminolevulinic acid, with photosensitizer prodrug activity. Methyl-5-aminolevulinate in the cream is selectively absorbed by tumor cells upon topical administration, where it is converted to the photosensitizer protoporphyrin IX (PpIX). After photoirradiation, PpIX is activated and transfers energy to oxygen, generating singlet oxygen and superoxide and hydroxyl radicals, which may result in free-radical-mediated DNA damage and cell death.
| References |
Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):793-5.
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|---|---|
| Additional Infomation |
See also: Methyl Aminolevulinate (has active moiety).
Drug Indication Treatment of acne vulgaris |
| Molecular Formula |
C6H12CLNO3
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|---|---|
| Molecular Weight |
181.6174
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| Exact Mass |
181.05
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| CAS # |
79416-27-6
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| Related CAS # |
Methyl aminolevulinate;33320-16-0
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| PubChem CID |
157921
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| Appearance |
White to off-white solid powder
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| Boiling Point |
228ºC at 760 mmHg
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| Melting Point |
122 °C
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| Flash Point |
99.5ºC
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| LogP |
0.969
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
11
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| Complexity |
133
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
UJYSYPVQHFNBML-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H11NO3.ClH/c1-10-6(9)3-2-5(8)4-7;/h2-4,7H2,1H3;1H
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| Chemical Name |
methyl 5-amino-4-oxo-pentanoate hydrochloride
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| Synonyms |
5-Aminolevulinic acid methyl ester; LS-187769; LS 187769; LS187769; MAL; Aminolevulinic acid methyl ester; methyl 5-amino-4-oxopentanoate; methyl 5-aminolevulinate; Methyl aminolevulinate hydrochloride. brand name: Metvix.
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~550.60 mM)
DMSO : ~100 mg/mL (~550.60 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.77 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (13.77 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (13.77 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.5060 mL | 27.5300 mL | 55.0600 mL | |
| 5 mM | 1.1012 mL | 5.5060 mL | 11.0120 mL | |
| 10 mM | 0.5506 mL | 2.7530 mL | 5.5060 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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