| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
In human NK cells, MF-766 (0.01-10 μM; 1 hour off, stimulated with 50 ng/mL IL-2; with and 0.33 μM PGE2; 18 hours) recovers PGE2 and then IFN-γ without inhibition. MF-766 does not influence the activity of NK cells [2].
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|---|---|
| ln Vivo |
In the CT26 model, MF-766 (medial gavage; 30 mg/kg; once daily; tumor day 21) showed 49% tumor inhibition. EMT6 and 4T1 tumor models, on the other hand, did not exhibit any appreciable differences [2 MF-766 (oral gavage; 30 mg/kg coupled with anti-PD-1 mDX400; once daily; 21 days; q4dx8) in several preclinical models Shows strong anti-tumor efficacy. Tumor inhibition rates were 89%, 66%, and 40%, respectively, in 4T1 tumor models, EMT6 tumors, and CT26 tumors [2].
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| Animal Protocol |
Animal/Disease Models: Female C57BL/6 J strain mice were subcutaneously (sc) (sc) injected with CT26, EMT6 or 4T1 cells [2]
Doses: 30 mg/kg combined with anti-PD-1 mDX400: po (oral gavage); 10 mg/kg or 30 mg/kg kg in combination with anti-PD-1 mDX400; one time/day; day 21; q4dx8 Experimental Results: Antitumor activity was improved with PD-1 blockade in multiple syngeneic models. |
| References |
|
| Molecular Formula |
C27H21F3N2O3
|
|---|---|
| Molecular Weight |
478.4712
|
| Exact Mass |
478.15
|
| CAS # |
1050656-06-8
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| PubChem CID |
25003075
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| Appearance |
Off-white to gray solid powder
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| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
711.4±60.0 °C at 760 mmHg
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| Flash Point |
384.1±32.9 °C
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| Vapour Pressure |
0.0±2.4 mmHg at 25°C
|
| Index of Refraction |
1.628
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| LogP |
5.12
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
35
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| Complexity |
783
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
BWXAZFCPGFKANL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C27H21F3N2O3/c28-27(29,30)21-8-4-17(5-9-21)16-32-15-12-18-2-1-3-22(23(18)32)24(33)31-26(13-14-26)20-10-6-19(7-11-20)25(34)35/h1-12,15H,13-14,16H2,(H,31,33)(H,34,35)
|
| Chemical Name |
4-[1-[[1-[[4-(trifluoromethyl)phenyl]methyl]indole-7-carbonyl]amino]cyclopropyl]benzoic acid
|
| Synonyms |
MF766; MF 766; MF-766
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~104.50 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.23 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0900 mL | 10.4500 mL | 20.9000 mL | |
| 5 mM | 0.4180 mL | 2.0900 mL | 4.1800 mL | |
| 10 mM | 0.2090 mL | 1.0450 mL | 2.0900 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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