Size | Price | Stock | Qty |
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1mg |
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Other Sizes |
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ln Vitro |
Apolipoprotein (apo) B is a large amphipathic protein that plays an important role in the functioning of human lipoproteins. Mipomersen is primarily distributed in the liver and reduces the production of apoB-100, the main structural protein of atherogenic lipoproteins, including low-density lipoprotein (LDL). This lowers heart disease LDL-cholesterol and apoB-100 concentrations. Additionally, ApoB-100 binds to the LDL receptor and facilitates the endocytosis of LDL [2].
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References |
[1]. Philip Hair, et al. Mipomersen sodium: first global approval. Drugs. 2013 Apr;73(5):487-93.
[2]. Damon A Bell, et al. Mipomersen, an antisense apolipoprotein B synthesis inhibitor. Expert Opin Investig Drugs. 2011 Feb;20(2):265-72. |
CAS # |
629167-92-6
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Related CAS # |
Mipomersen;1000120-98-8
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~100 mg/mL (~13.17 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (13.17 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.