| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| 25g |
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| Other Sizes |
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| Targets |
Biological buffer
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|---|---|
| ln Vitro |
The values of the second dissociation constant, pK2, and related thermodynamic quantities of 4-(N-morpholino)butanesulfonic acid (MOBS) and N-tris(hydroxymethyl)-4-aminobutanesulfonic acid (TABS) have already been reported over the temperature range 5–55°C including 37{°}C. This paper reports the pH values of twelve equimolal buffer solutions at designated pH (s) with the following compositions: (a) mixtures of MOBS (0.05 mol-kg−1) + NaMOBS (0.05 mol-kg−1); (b) MOBS (0.08 mol-kg−1) + NaMOBS (0.08 mol-kg−1); (c) MOBS (0.08 mol-kg−1) + NaMOBS (0.08 mol-kg−1) + NaCl (0.08 mol-kg−1); (d) TABS (0.05 mol-kg−1) + NaTABS (0.05 mol-kg−1); and (e) TABS (0.08 mol-kg−1) + NaTABS (0.08 mol-kg−1); and (f) TABS (0.08 mol-kg−1) + NaTABS (0.08 mol-kg−1) + NaCl (0.08 mol-kg−1). Two buffer solutions have ionic strengths I= 0.05 mol-kg−1, another two have I=0.08 mol-kg−1, and the remaining two buffer solutions have I= 0.16 mol-kg−1, which is close to that of the clinical fluids (blood serum). These buffers have been recommended as a useful pH standard for the measurements of physiological solutions. Conventional pH values of all six buffer solutions from 5–55°C, as well as those obtained from the liquid junction potential correction at 25 and 37{°}C have been calculated. The flowing-junction calomel cell has been utilized to measure Ej, the liquid junction potential.[1]
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| References |
| Molecular Formula |
C8H17NO4S
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|---|---|
| Molecular Weight |
223.28988
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| Exact Mass |
223.088
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| CAS # |
115724-21-5
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| PubChem CID |
3674064
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| Appearance |
White to off-white solid powder
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| LogP |
1.005
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
14
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| Complexity |
241
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
VTOWJTPBPWTSMK-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H17NO4S/c10-14(11,12)8-2-1-3-9-4-6-13-7-5-9/h1-8H2,(H,10,11,12)
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| Chemical Name |
4-morpholin-4-ylbutane-1-sulfonic acid
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| Synonyms |
MOBS; 4-Morpholinobutane-1-sulfonic acid; 4-morpholin-4-ylbutane-1-sulfonic Acid; 4-(N-Morpholino)butanesulfonic acid; 4-Morpholinebutanesulfonic acid; 4-(MORPHOLIN-4-YL)BUTANE-1-SULFONIC ACID; 4-morpholin-4-ium-4-ylbutane-1-sulfonate;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~125 mg/mL (~559.81 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4785 mL | 22.3924 mL | 44.7848 mL | |
| 5 mM | 0.8957 mL | 4.4785 mL | 8.9570 mL | |
| 10 mM | 0.4478 mL | 2.2392 mL | 4.4785 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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