Size | Price | Stock | Qty |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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ln Vitro |
In vitro, mogroside V (20 μM, 40 hours) lowers the levels of ROS in mature oocytes [1]. Mogroside V (20 μM, 40 hours) can improve the mitochondrial culture function of oocytes [1]. By modifying STAT3 signaling, mogroside V (1) -250 μM, 24 hours) stimulates pancreatic islet and cell cycle arrest in the pancreas (PANC-1) [3]. fluorescent imaging [1]
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ln Vivo |
In two diabetes models, the oral drug mogroside V (100 mg/kg) undergoes conversion into 26 metabolites via the processes of dehydrogenation, deoxygenation, oxidation, and carbonation [1].
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Cell Assay |
Immunofluorescence[1]
Cell Types: IVM o Members Tested Concentrations: 20 μM Incubation Duration: 40 hrs (hours) Experimental Results: Compared with the control group, the fluorescence intensity increased. The red/green fluorescence intensity ratio increased compared to the control group. Real-time qPCR[1] Cell Types: IVM Oocyte Tested Concentrations: 20 μM Incubation Duration: 40 h Experimental Results: The relative expression of SOD, CAT, PGC-1α and TFAM mRNA increased compared with the control group. Cell viability assay[3] Cell Types: PANC-1 Cell Tested Concentrations: 1-250 μM Incubation Duration: 24 hrs (hours) Experimental Results: The percentage of TUNEL-positive cells increased from 2.91% to 92.25%. Apoptosis analysis [3] Cell Types: PANC-1 Cell Tested Concentrations: 1-250 μM Incubation Duration: 24 hrs (hours) Experimental Results: Induction of PANC-1 cell apoptosis in a concentration- and time-dependent manner Western Blot analysis [3] Cell Types: PANC-1 Cell Tested Concentrations: 0-250 μM Incubation Duration: 24 hrs (hours) Experimental Results: Expression of cyclin kinase inhibitors CDKN1A (p21WAF1) and CDKN1B (p27) incre |
Animal Protocol |
Animal/Disease Models: T2D model rat [2] ]
Doses: 100 mg/kg Route of Administration: po (oral gavage) Experimental Results: Compared with blank biological samples, 28 mogroside V metabolites were detected. Metabolite peak areas in plasma samples from T2D rats were larger than those in healthy samples. |
References |
[1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.
[2]. Nie J, et al. Mogroside V improves porcine oocyte in vitro maturation and subsequent embryonic development. Theriogenology. 2020 Jan 1;141:35-40. [3]. Zhou G, et al. The metabolism of a natural product mogroside V, in healthy and type 2 diabetic rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 15;1079:25-33. [4]. Liu C, et al. A natural food sweetener with anti-pancreatic cancer properties. Oncogenesis. 2016 Apr 11;5(4):e217. |
Molecular Formula |
C60H102O29
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Molecular Weight |
1287.43
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CAS # |
88901-36-4
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
C[C@@]([C@@](CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]1O)O)([H])O[C@@H]1CO[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)C3(C)C)([H])C3=CC4)([C@@H](C[C@@]56C)O)[C@]4([H])[C@@]5(CC[C@]6([H])[C@H](C)CC[C@H](C(C)(O)C)O[C@H](O[C@H](CO[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO)[C@@H](O)[C@@H]8O)[C@@H]8O[C@]([C@@H]([C@@H](O)[C@@H]9O)O)([H])O[C@@H]9CO)C
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~77.67 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (1.62 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (1.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (1.62 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.7767 mL | 3.8837 mL | 7.7674 mL | |
5 mM | 0.1553 mL | 0.7767 mL | 1.5535 mL | |
10 mM | 0.0777 mL | 0.3884 mL | 0.7767 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.