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Purity: ≥98%
Moxifloxacin (Avelox, Avalox, Avelon, Vigamox, Moxeza; BAY12-8039; BAY12-8039; BAY 12-8039) is an orally bioactive, broad spectrum and 4th generation antibiotic agent of the fluoroquinolone class with high activity against both Gram positive and Gram negative bacteria. It acts as an inhibitor of DNA topoisomerase II and topoisomerase IV.
| Targets |
Quinolone
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|---|---|
| ln Vitro |
The time-kill curve and inhibition of intracellular growth experiments are used to compare the in vitro activities of loxifloxacin and amoxicillin using a model of L. monocytogenes EGDe-infected mouse macrophages derived from bone marrow. Much more quickly, doxifloxacin starts to work in the first three hours of incubation and completely sterilizes the broth in the final twenty-four hours. Many of the cells are still alive after a 24-hour incubation period, suggesting that doxifloxacin may have a protective effect against macrophage lysis[3].
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| ln Vivo |
Longer survival is associated with doxifloxacin (12 mg/kg; intravenous injection; once-three times daily; for 7 days; white male Wistar rats). Thirty hours after the bacterial challenge, tissue cultures reveal significantly less bacterial overgrowth in the lungs and spleens of moxifloxacin-treated animals than in saline-treated animals, and without any toxic effects[4].
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| Animal Protocol |
Animal Model: Stenotrophomonas maltophilia infected 144 white male Wistar rats, weighing 300–400 g and maturing between 18 and 22 weeks[4].
Dosage: 12 mg/kg Administration: Intravenous injection; once per day, twice per day, three times per day; for 7 days Result: demonstrated a marked reduction in the overgrowth of bacteria in the lungs and spleens without being toxic. |
| References |
| Molecular Formula |
C21H24FN3O4
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|---|---|
| Molecular Weight |
401.43
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| Exact Mass |
401.18
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| Elemental Analysis |
C, 62.83; H, 6.03; F, 4.73; N, 10.47; O, 15.94
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| CAS # |
151096-09-2
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| Related CAS # |
Moxifloxacin Hydrochloride;186826-86-8;(Rac)-Moxifloxacin;354812-41-2;Moxifloxacin-d4;2596386-23-9;Moxifloxacin-d3 hydrochloride;2734919-98-1;Moxifloxacin-d3-1 hydrochloride;1246816-75-0;Moxifloxacin-13C,d3 hydrochloride;rac cis-Moxifloxacin-d4 hydrochloride;1217802-65-7
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| Appearance |
Solid powder
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| SMILES |
Cl[H].FC1C([H])=C2C(C(C(=O)O[H])=C([H])N(C2=C(C=1N1C([H])([H])[C@]2([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])N2[H])C1([H])[H])OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H])=O
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| InChi Key |
FABPRXSRWADJSP-MEDUHNTESA-N
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| InChi Code |
InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1
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| Chemical Name |
1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid
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| Synonyms |
Avelox;Avalox;Avelon;Vigamox;Moxeza;BAY12-8039;BAY12-8039;BAY 12-8039
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~31.25 mg/mL (~77.85 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.23 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.23 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.23 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4911 mL | 12.4555 mL | 24.9109 mL | |
| 5 mM | 0.4982 mL | 2.4911 mL | 4.9822 mL | |
| 10 mM | 0.2491 mL | 1.2455 mL | 2.4911 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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