| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| ln Vitro |
Compared to MPEP, MTEP is less off-target and has a different selectivity for mGluR5 than mGluR1, while MPEP has no effect on other mGluR subtypes [1].
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| ln Vivo |
The catalepsy coefficient caused by haloperidol (0.5 mg/kg, i.p.) is inhibited by MTEP (0-5 mg/kg, i.p., once) [2]. MTEP (0.3-3 mg/kg, i.p., once) is in control.
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| Animal Protocol |
Animal/Disease Models: Male Wistar rats (215-315 g, 5-9/group) [2] Doses: 1, 3, and 5 mg/kg given Medication method: IP, inducing antidepressant-like effects in C57BL/6J mice [3]. One injection, 60 minutes after haloperidol (0.5 mg/kg/2 ml ip)
Experimental Results:Inhibition of haloperidol-induced rigor. Animal/Disease Models: Male C57BL/6J mice (23-25 g) [3] Doses: 0.3, 1 and 3 mg/kg Route of Administration: intraperitoneal (ip) injection, 1 hour before test Experimental Results: Dramatically diminished mice in the tail suspension test Immobility time (Tsim Sha Tsui) increased by 24%, 41% and 48% respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not Dramatically different from that of imipramine (20 mg/kg, i.p.) used as a positive standard. |
| References |
[1]. Lea PM 4th, et al. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 2006 Summer;12(2):149-66.
[2]. Ossowska K, et al. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Neuropharmacology. 2005 Sep;49(4):447-55. [3]. Pałucha A, et al. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005 Aug;81(4):901-6. [4]. Klodzinska A, et al. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling. Neuropharmacology. 2004 Sep;47(3):342-50. |
| Molecular Formula |
C11H9CLN2S
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|---|---|
| Molecular Weight |
236.720559835434
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| CAS # |
1186195-60-7
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| Related CAS # |
MTEP;329205-68-7
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
Cl.S1C=C(C#CC2C=NC=CC=2)N=C1C
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~20 mg/mL (~84.49 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (422.44 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2244 mL | 21.1220 mL | 42.2440 mL | |
| 5 mM | 0.8449 mL | 4.2244 mL | 8.4488 mL | |
| 10 mM | 0.4224 mL | 2.1122 mL | 4.2244 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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