Size | Price | Stock | Qty |
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5mg |
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10mg |
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Other Sizes |
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ln Vitro |
In PC12D cells, naredosinone (0.1–100 microM) concentration-dependently promotes neurite outgrowth triggered by staurosporine (10 nM) and dibutyryl cyclic AMP (dbcAMP, 0.3 mM). In the MAP kinase-dependent signaling pathway, nandosinone amplifies the downstream actions of MAP kinase [1].
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References |
[1]. Li P, et al. Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells.Brain Res Dev Brain Res. 2003 Nov 12;145(2):177-83.
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Molecular Formula |
C15H22O3
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Molecular Weight |
250.3334
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Exact Mass |
250.16
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Elemental Analysis |
C, 71.97; H, 8.86; O, 19.17
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CAS # |
23720-80-1
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Appearance |
Solid powder
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SMILES |
C[C@@H]1CCC=C2[C@]1([C@H]3[C@@H](CC2=O)OOC3(C)C)C
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InChi Key |
KXGHHSIMRWPVQM-JWFUOXDNSA-N
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InChi Code |
InChI=1S/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1
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Chemical Name |
(3aR,9R,9aR,9bS)-1,1,9,9a-tetramethyl-3a,4,7,8,9,9b-hexahydronaphtho[2,1-c]dioxol-5-one
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Synonyms |
Nardosinone
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~250 mg/mL (~998.68 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.9947 mL | 19.9736 mL | 39.9473 mL | |
5 mM | 0.7989 mL | 3.9947 mL | 7.9895 mL | |
10 mM | 0.3995 mL | 1.9974 mL | 3.9947 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.