Size | Price | Stock | Qty |
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1mg |
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2mg |
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5mg |
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10mg |
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25mg |
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Other Sizes |
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ln Vitro |
Nesiritide, also known as Brain Natriuretic Peptide-32 human, is an agonist of the natriuretic peptide receptor (NPR), with Kd values of 7.3 pM for NPR-A and 13 pM for NPR-C [1]. While ProBNP1-108 is 13 times less powerful than Nesiritide (BNP1-32), it nevertheless stimulates guanylate cyclase-A (GC-A) to almost maximal activity. Nesiritide binds to human GC-A 35 times more strongly than ProBNP1-108. Nesiritide and proBNP1-108 do not activate GC-B. Compared to nesiritide, the binding strength of natriuretic peptide scavenging receptors to proBNP1-108 is three times lower. When degraded by human renal membrane, proBNP1-108 has a half-life that is 2.7 times longer than that of nesiritide and a complete degradation period that is 6 times longer. The first-order and second-order exponential decay models are best fitted by nesiritide and proBNP1-108, respectively [2].
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References |
[1]. Koller KJ, et al. Molecular biology of the natriuretic peptides and their receptors. Circulation. 1992 Oct;86(4):1081-8.
[2]. Dickey DM, et al. ProBNP(1-108) is resistant to degradation and activates guanylyl cyclase-A with reduced potency. Clin Chem. 2011 Sep;57(9):1272-8. |
Molecular Formula |
C143H244N50O42S4
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Molecular Weight |
3464.05
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CAS # |
124584-08-3
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
CC[C@@H]([C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC2=CN=CN2)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(C)C)=O)C(C)C)=O)CCCCN)=O)CSSC[C@H](NC(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]3CCCN3C([C@@H](N)CO)=O)=O)CCCCN)=O)CCSC)=O)C(C)C)=O)CCC(N)=O)=O)=O)CO)=O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CCSC)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC(C)C)=O)=O)CO)=O)CO)=O)CO)=O)CO)=O)C
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Synonyms |
Nesiritide Brain Natriuretic Peptide-32 human
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ≥ 40 mg/mL (~11.55 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (28.87 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.2887 mL | 1.4434 mL | 2.8868 mL | |
5 mM | 0.0577 mL | 0.2887 mL | 0.5774 mL | |
10 mM | 0.0289 mL | 0.1443 mL | 0.2887 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.