Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
NLG919 analog (RG6078 analog; GDC-0919 analog; GDC0919 analog; IDO-IN-7; NLG-919 analog) is a novel, potent and orally bioavailable inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with potential immunomodulating and antitumor activity. It inhibits IDO1 with Ki/EC50 of 7 nM/75 nM in cell-free assays. IDO1 catalyzes the conversion of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, NLG919 analog increases tryptophan levels, restores the proliferation and activation of immune cells (e.g. NK cells, T-lymphocytes), leading to a reduction in tumor-associated regulatory T-cells.
ln Vitro |
Strong IDO1 inhibitor IDO-IN-7 (analogue of NLG-919) has an IC50 of 38 nM. IDO-IN-7's binding mode to IDO1 is accessible through experimentation and demonstrates a direct coordination interaction with the ferric heme's sixth coordination site. In previous research, IDO-IN-7 was utilized as a reference drug to build immunostimulatory nanomicellar carriers and verify high-throughput screening assays for IDO1 inhibition[1].
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ln Vivo |
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Animal Protocol |
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References |
[1]. Coletti A, et al. Fragment-based approach to identify IDO1 inhibitor building blocks. Eur J Med Chem. 2017 Dec 1;141:169-177
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Molecular Formula |
C18H22N2O
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Molecular Weight |
282.38
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CAS # |
1402836-58-1
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SMILES |
OC(C1CCCCC1)CC(C2=C3C=CC=C2)N4C3=CN=C4
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.5413 mL | 17.7066 mL | 35.4133 mL | |
5 mM | 0.7083 mL | 3.5413 mL | 7.0827 mL | |
10 mM | 0.3541 mL | 1.7707 mL | 3.5413 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.