Size | Price | Stock | Qty |
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5g |
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10g |
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25g |
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50g |
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Other Sizes |
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Purity: ≥98%
Norepinephrine (Levarterenol; L-Noradrenaline) is a potent and β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. Norepinephrine is an organic compound that belongs to the catecholamine family and is used by the body and brain as a neurotransmitter and hormone. It is a chemical that occurs naturally in the body and functions as a neurotransmitter (a material that transmits signals between nerve cells) as well as a stress hormone. When the brain believes that a stressful event has occurred, it releases this hormone into the bloodstream.
Targets |
α1-adrenergic receptor; α2-adrenergic receptor; Beta-1 adrenergic receptor; Microbial Metabolite; Human Endogenous Metabolite
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ln Vitro |
Norepinephrine (NE) is typically thought to be a β2-initiator receptor and an β1-subtype β1-initiator agonist. At lower concentrations, norepinephrine (NE) also exhibits direct activity on β2-initiator receptors [1]. From newborn wild-type C57BL/6J mice, the inguinal fat pad (iWA) or intershoulder fat pad (BA) were separated and cultured. cAMP production in response to co-treatment with norepinephrine (NE, 10 μM) with or without CGP (10 nM) was first measured in order to investigate the impact of activating AT2 on β-primergic signaling. NE, or norepinephrine, raises cAMP. As anticipated in iWA, CGP doesn't change this result. In addition to stimulating heat production and requiring released media for the functional activation of the UCP1 protein, norepinephrine (NE) is also known to cause fat loss.
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ln Vivo |
Norepinephrine can be utilized to create animal models in animal models.
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Cell Assay |
Subcutaneous preadipocytes are immortalized with TERT and HPV E6/E7 from a 38-year-old female donor who is not diabetic. To facilitate the current investigations, ring cloning is used to isolate a stable diploid clone (called clone B) with a constant capacity for differentiation. Proadipocyte PGM2 medium is used to cultivate cells. Incubation in differentiation media containing dexamethasone, IBMX, indomethacin, and extra insulin induces differentiation in cells once they are confluent. During ten days, cells differentiate. The media used for treatments is changed to serum-free media overnight after being replaced with PGM2 media for a day. NE (10 μM), CGP (10 nM), vehicle, or NE and CGP are the treatments given to adipocytes for six hours[2].
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References |
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Molecular Formula |
C8H11NO3
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Molecular Weight |
169.1778
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Exact Mass |
169.07
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Elemental Analysis |
C, 56.80; H, 6.55; N, 8.28; O, 28.37
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CAS # |
51-41-2
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Related CAS # |
Norepinephrine hydrochloride; 329-56-6; Norepinephrine bitartrate monohydrate; 108341-18-0; Norepinephrine tartrate; 51-40-1; (Rac)-Norepinephrine-d3 (formate)
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Appearance |
Solid powder
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SMILES |
C1=CC(=C(C=C1[C@H](CN)O)O)O
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InChi Key |
SFLSHLFXELFNJZ-QMMMGPOBSA-N
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InChi Code |
InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
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Chemical Name |
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
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Synonyms |
Norepinephrine; Noradrenaline; Noradrenalin; Levarterenol; Levophed Arterenol
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~25 mg/mL (~147.8 mM)
H2O: < 0.1 mg/mL
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (12.29 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (12.29 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (12.29 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.9109 mL | 29.5543 mL | 59.1086 mL | |
5 mM | 1.1822 mL | 5.9109 mL | 11.8217 mL | |
10 mM | 0.5911 mL | 2.9554 mL | 5.9109 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT04501861 | Active Recruiting |
Drug: Norepinephrine Drug: Vasopressin |
Cardiac Disease | The Cleveland Clinic | November 5, 2020 | Phase 3 |
NCT04597190 | Active Recruiting |
Drug: Selective serotonin reuptake inhibitor Behavioral: Written Exposure Therapy |
PTSD | University of Washington | April 1, 2021 | Phase 4 |
NCT04060381 | Active Recruiting |
Drug: Blood transfusion, Ibuprofen, or epinephrine, norepinephrine or dopamine |
Newborn Morbidity Maternal Obesity |
Haukeland University Hospital | April 4, 2017 | N/A |
NCT06102382 | Not yet recruiting | Drug: Norepinephrine (0.1) Drug: Norepinephrine (0.075) |
Hypotension Norepinephrine |
Assiut University | December 10, 2023 | Not Applicable |
NCT06121115 | Recruiting | Drug: Norepinephrine | Septic Shock Hypotension and Shock |
Region Skane | October 3, 2023 | N/A |
Norepinephrine (NE) released in the PFC activates different intracellular signaling pathways through distinct adrenoceptors with varying affinities for NE. Pharmacol Ther . 2007 Mar;113(3):523-36. td> |
AT2 activation suppresses norepinephrine induced UCP1 in white adipocytes (iWA). Cell Rep . 2016 Aug 9;16(6):1548-1560. td> |
Metadynamics simulations reveal different norepinephrine entrance pathway in the β1AR and β2AR. Cell Res . 2021 May;31(5):569-579. td> |
Analysis of different residues on the extracellular domain of the receptors that contribute to the different norepinephrine-binding pathway. Cell Res . 2021 May;31(5):569-579. td> |