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Purity: ≥98%
Olaflur (GA-297; SKF-38095J2; amine fluoride 297) is a fluoride-containing and cariostatic chemical substance that is used as an ingredient of toothpastes and solutions for the prevention of dental caries. It has been in use since 1966. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Basically, it is a fluoride treatment for patients at risk of dental caries, sensitive teeth, or enamel decalcification. Olaflur is a salt composed of an alkyl ammoniumcation and fluoride as the counterion. With a long lipophilichydrocarbonchain, the cation has surfactantproperties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel.
| References |
Barrak I, Urbán E, Turzó K, Nagy K, Braunitzer G, Stájer A. Short- and Long-Term Influence of Fluoride-Containing Prophylactics on the Growth of Streptococcus mutans on Titanium Surface. Implant Dent. 2015 Dec;24(6):675-9.
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| Additional Infomation |
Olaflur which is also referred to as elmex gel is an ingredient used in toothpaste which helps in the prevention of dental caries.
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| Molecular Formula |
C27H60F2N2O3
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|---|---|
| Molecular Weight |
498.785
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| Exact Mass |
498.457
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| CAS # |
6818-37-7
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| Related CAS # |
6818-37-7 (HF);7671-49-7;
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| PubChem CID |
23257
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| Appearance |
Typically exists as solid at room temperature
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| Boiling Point |
583.5ºC at 760 mmHg
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| Flash Point |
255.7ºC
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| LogP |
6.284
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| Hydrogen Bond Donor Count |
5
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
27
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| Heavy Atom Count |
34
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| Complexity |
339
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| Defined Atom Stereocenter Count |
0
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| SMILES |
F.F.CCCCCCCCCCCCCCCCCC(N(CCCN)CCO)(CCO)CCO
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| InChi Key |
ZVVSSOQAYNYNPP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C27H58N2O3.2FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-28(22-25-30)20-18-21-29(23-26-31)24-27-32/h30-32H,2-27H2,1H32*1H
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| Chemical Name |
Ethanol, 2,2'-[[3-[(2-hydroxyethyl)octadecylamino]propyl]imino]bis-, dihydrofluoride
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| Synonyms |
Amine fluoride 297GA-297 OlaFluorAmF 297 GA297SKF-38095J2 Amine fluoride SKF38095J2Olaflur
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| HS Tariff Code |
2934.99.9001
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| Storage |
Room tempreture for 1 year.
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| Shipping Condition |
Room temperature
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0049 mL | 10.0243 mL | 20.0485 mL | |
| 5 mM | 0.4010 mL | 2.0049 mL | 4.0097 mL | |
| 10 mM | 0.2005 mL | 1.0024 mL | 2.0049 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT01329731 | Completed | Drug: elmex® gelée Drug: negative control (placebo) |
Tooth; Lesion, White Spot Lesions | Gaba International AG | March 2011 | Phase 4 |
| NCT00681135 | Completed | Device: manual toothbrush (elmex® Inter X medium toothbrush) |
Dental Plaque Gingivitis |
Sebastian Zingler | April 2008 | Not Applicable |
| NCT00670618 | Completed | Device: Fluoride (Elmex Medical Gel) | Early Caries Lesions | University Hospital, Ghent | October 1, 2008 | Not Applicable |
| NCT05705037 | Recruiting | Other: CPP-ACPF Other: PBMT |
Dentin Sensitivity Molar Incisor Hypomineralization |
Università degli Studi di Brescia | January 10, 2022 | Not Applicable |
Products are for research use only; We do not sell to patients
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