| Size | Price | Stock | Qty |
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| 25mg |
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| 100mg |
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| 250mg |
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| 500mg |
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Purity: ≥98%
Olanexidine HCl (also known as OPB-2045 HCl) is a novel monobiguanide analog with bactericidal activity. It was approved for use in Japan on Jul 03, 2015. Olanexidine is an antiseptic/disinfectant compound with potent bactericidal activity against Gram-negative and Gram-positive bacteria, for use in preparing patients for surgery and preventing of postoperative bacterial infections. Oanexidine probably binds to the cell membrane and disrupts membrane integrity and that its bacteriostatic and bactericidal effects are caused by irreversible leakage of intracellular components. At relatively high concentrations, olanexidine aggregates cells by denaturing proteins. This mechanism differs slightly from that of a similar biguanide compound, chlorhexidine.
| ln Vitro |
Olanexidine exhibits a bactericidal mechanism that involves interactions with molecules found on the surface of bacteria, such as lipopolysaccharide and lipoteichoic acid; disruption of liposome cell membranes, which are artificial models of bacterial membranes; enhancement of membrane permeability in Escherichia coli; disruption of S. aureus membrane integrity; and denature of proteins at relatively high concentrations (≥160 μg/ml)[1].
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| References |
Antimicrob Agents Chemother.2015 Aug;59(8):4551-9.
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| Molecular Formula |
C17H28CL3N5
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| Molecular Weight |
408.80
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| Elemental Analysis |
C, 49.95; H, 6.90; Cl, 26.02; N, 17.13
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| CAS # |
146509-94-6
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| Related CAS # |
Olanexidine;146510-36-3
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| Appearance |
Solid powder
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| SMILES |
N=C(NCC1=CC=C(Cl)C(Cl)=C1)NC(NCCCCCCCC)=N.[H]Cl
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| InChi Key |
GVBQOBUYEOFFLD-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H27Cl2N5.ClH/c1-2-3-4-5-6-7-10-22-16(20)24-17(21)23-12-13-8-9-14(18)15(19)11-13;/h8-9,11H,2-7,10,12H2,1H3,(H5,20,21,22,23,24);1H
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| Chemical Name |
-((3,4-Dichlorophenyl)methyl)-N'-octylimidodicarbonimidic diamide monohydrochloride
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~62.5 mg/mL (~152.89 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.09 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. Solubility in Formulation 2: 10% DMSO+90% Corn Oil: ≥ 2.08 mg/mL (5.09 mM) (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4462 mL | 12.2309 mL | 24.4618 mL | |
| 5 mM | 0.4892 mL | 2.4462 mL | 4.8924 mL | |
| 10 mM | 0.2446 mL | 1.2231 mL | 2.4462 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Effects of olanexidine and chlorhexidine on calcein release from calcein-encapsulated LUVs with different lipid compositions after 11 min of exposure.Antimicrob Agents Chemother.2015 Aug;59(8):4551-9. |
Changes in outer and inner membrane permeabilization caused by olanexidine and chlorhexidine in E. coli ML-35p cells incubated in 5 mM HEPES buffer containing 20 μg/ml nitrocefin and 5 μM carbonyl cyanide 3-chlorophenylhydrazone with olanexidine gluconate (A) or chlorhexidine digluconate (B). |
Effects of olanexidine and chlorhexidine on the cytoplasmic membrane of S. aureus. The effects were monitored by changes in the membrane potential using a fluorescence probe, DiSC3(5). (A) Olanexidine gluconate. (B) Chlorhexidine digluconate. Distilled water (DW) was used as a negative control.Antimicrob Agents Chemother.2015 Aug;59(8):4551-9. |
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