Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Purity: ≥98%
Omadacycline HCl (PTK-0796; trade name: Nuzyra), the hydrochloride salt of omadacycline, is an aminomethyl tetracycline antibiotic approved in 2018 to treat community-acquired bacterial infections such as acute bacterial skin and skin structure infections (ABSSSI), community-acquired bacterial pneumonia (CABP), and urinary tract infections (UTI).
Targets |
Tetracycline
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ln Vitro |
With MIC90s of 1.0, 0.25, 0.5, 0.25, and 2.0 μg/mL, respectively, omadacycline shows activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP), and Haemophilus influenzae (H. influenzae)[2].
Through ribosomal protection and active tetracycline efflux, omadacycline effectively combats strains that express resistance to tetracycline and other antibiotics[2].
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ln Vivo |
In a mouse systemic infection model, omadacycline (0.11–18 mg/kg; a single intravenous dose) shows effectiveness against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg[2].
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Animal Protocol |
Mice: Sterile saline is used to dissolve omadacycline. A 3-mL lock-top sterile syringe with a sterile 25-gauge, 5/8-in. needle is used to infect mice. Mice are given an intravenous (i.v.) dose of omadacycline or relevant comparator compounds at a volume of 10 ml/kg at one hour post-infection (p.i.). Each experiment involves testing a minimum of four dose levels on five mice per group. With a few notable exceptions, the usual dose range tested is 0.11 to 18 mg/kg of body weight[1]. Significantly higher or lower doses are needed for comparators to achieve 50% efficacy.
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References |
Molecular Formula |
C29H41CLN4O7
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Molecular Weight |
593.11
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Elemental Analysis |
C, 58.73; H, 6.97; Cl, 5.98; N, 9.45; O, 18.88
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CAS # |
1196800-39-1
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Related CAS # |
Omadacycline;389139-89-3;Omadacycline tosylate;1075240-43-5;Omadacycline-d9;2272886-41-4;Omadacycline mesylate;1196800-40-4
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Appearance |
Solid powder
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SMILES |
O=C(C1=C(O)[C@@H](N(C)C)[C@@](C[C@@]2([H])C(C(C3=C(O)C(CNCC(C)(C)C)=CC(N(C)C)=C3C2)=O)=C4O)([H])[C@@]4(O)C1=O)N.[HCl]
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InChi Key |
HXMCZSICOWSBRX-XGLFQKEBSA-N
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InChi Code |
InChI=1S/C29H40N4O7.ClH/c1-28(2,3)12-31-11-14-10-17(32(4)5)15-8-13-9-16-21(33(6)7)24(36)20(27(30)39)26(38)29(16,40)25(37)18(13)23(35)19(15)22(14)34;/h10,13,16,21,31,34,36-37,40H,8-9,11-12H2,1-7H3,(H2,30,39);1H/t13-,16-,21-,29-;/m0./s1
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Chemical Name |
(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
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Synonyms |
Omadacycline HCl; Omadacycline hydrochloride; PTK 0796; PTK-0796; PTK0796; Amadacyclin; Omadacycline; Nuzyra.
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : 200 mg/mL (~!337.21 mM)
DMSO : 50 mg/mL (~84.30 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.62 mg/mL (4.42 mM) (saturation unknown) in 5% DMSO + 95% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: 50 mg/mL (84.30 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.6860 mL | 8.4301 mL | 16.8603 mL | |
5 mM | 0.3372 mL | 1.6860 mL | 3.3721 mL | |
10 mM | 0.1686 mL | 0.8430 mL | 1.6860 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.