Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
Orteronel racemate, the mixture of S-enantiomer and R-enantiomer of Orteronel (aslo known as TAK-700) which is a novel, potent and highly selective, orally bioavailable non-steroidal androgen synthesis inhibitor of human 17,20-lyase inhibitor with IC50 of 38 nM, it exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). TAK-700 has potential antiandrogen activity by binding to and inhibiting the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells.
ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
:Bioorg Med Chem.2011 Nov 1;19(21):6383-99;J Steroid Biochem Mol Biol.2012 Apr;129(3-5):115-28.
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Molecular Formula |
C18H17N3O2
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Molecular Weight |
307.35
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Exact Mass |
307.13
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Elemental Analysis |
C, 70.34; H, 5.58; N, 13.67; O, 10.41
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CAS # |
426219-18-3
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Related CAS # |
426219-18-3 (racemic);566939-85-3 (s-isomer);
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Appearance |
Solid powder
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SMILES |
O=C(NC)C1=CC=C2C=C(C3(O)CCN4C=NC=C43)C=CC2=C1
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.2536 mL | 16.2681 mL | 32.5362 mL | |
5 mM | 0.6507 mL | 3.2536 mL | 6.5072 mL | |
10 mM | 0.3254 mL | 1.6268 mL | 3.2536 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.