| Size | Price | Stock | Qty |
|---|---|---|---|
| 25g |
|
||
| Other Sizes |
|
| ln Vivo |
The surface area and wet weight of cotton ball granuloma can be greatly reduced by oxapropanol at a dose of 6 mg/kg each day for 7 days. Its effectiveness is somewhat greater than that of indomethacin at 3 mg/kg. Oxapropanol, when administered therapeutically (6–54 mg/kg/day), suppresses subsequent lesions in the ears and tail but has no effect on the main paw edema response [3]. While oxapropanol greatly reduces neutrophil infiltration into the joints of rats suffering from adjuvant arthritis, it has no effect on prostaglandin generation in vitro [4].
|
|---|---|
| Animal Protocol |
Animal/Disease Models: Male SD (SD (Sprague-Dawley)) rat [3].
Doses: 18, 50 or 150 mg/kg. Route of Administration: Administer daily for 15 days. Experimental Results: The inhibitory effect on hyperalgesia was comparable to that of indomethacin. |
| References |
|
| Molecular Formula |
C7H11NO4
|
|---|---|
| Molecular Weight |
173.16
|
| Exact Mass |
173.068
|
| CAS # |
33996-33-7
|
| PubChem CID |
65784
|
| Appearance |
White to off-white solid powder
|
| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
442.1±45.0 °C at 760 mmHg
|
| Melting Point |
132-133 °C (dec.)(lit.)
|
| Flash Point |
221.2±28.7 °C
|
| Vapour Pressure |
0.0±2.4 mmHg at 25°C
|
| Index of Refraction |
1.561
|
| LogP |
-2.04
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
12
|
| Complexity |
216
|
| Defined Atom Stereocenter Count |
2
|
| SMILES |
CC(=O)N1C[C@@H](C[C@H]1C(=O)O)O
|
| InChi Key |
BAPRUDZDYCKSOQ-RITPCOANSA-N
|
| InChi Code |
InChI=1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
|
| Chemical Name |
(2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid
|
| Synonyms |
AHP 200; Jonctum; Oxaceprol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~577.47 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.44 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.44 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.7750 mL | 28.8750 mL | 57.7501 mL | |
| 5 mM | 1.1550 mL | 5.7750 mL | 11.5500 mL | |
| 10 mM | 0.5775 mL | 2.8875 mL | 5.7750 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
