| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| Other Sizes |
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| ln Vitro |
Oxypurinol is the active metabolite of allopurinol, which is produced at a rapid rate (half-life of about 1 hour). Two xanthine oxidoreductase enzymes are present in oxypurinol, which has a relatively long elimination half-life (about 23 hours) [1].
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|---|---|
| ADME/Pharmacokinetics |
Biological Half-Life
23.3 +/- 6.0 hours |
| References | |
| Additional Infomation |
Alloxanthine is a pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6. It has a role as an EC 1.17.3.2 (xanthine oxidase) inhibitor and a drug metabolite.
Oxypurinol, an inhibitor of xanthine oxidase, is a metabolite of allopurinol. Oxypurinol has been reported in Asterias amurensis, Mytilus coruscus, and other organisms with data available. A xanthine oxidase inhibitor. Drug Indication Intended for the treatment of congestive heart failure and hyperuricemia. Mechanism of Action Oxypurinol inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid. Elevated concentrations of oxypurine and oxypurine inhibition of xanthine oxidase through negative feedback results in a decrease in the concentrations of uric acid in the blood and urine. Oxypurinol also facilitates the incorporation of hypoxanthine and xanthine into DNA and RNA, resulting in further reductions of serum uric acid concentrations. |
| Molecular Formula |
C5H4N4O2
|
|---|---|
| Molecular Weight |
152.113
|
| Exact Mass |
152.033
|
| Elemental Analysis |
C, 39.48; H, 2.65; N, 36.83; O, 21.04
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| CAS # |
2465-59-0
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| PubChem CID |
135398752
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| Appearance |
White to yellow solid powder
|
| Density |
2.19g/cm3
|
| Boiling Point |
662.9ºC at 760 mmHg
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| Melting Point |
300 °C
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| Flash Point |
354.7ºC
|
| Vapour Pressure |
3.5E-18mmHg at 25°C
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| Index of Refraction |
1.989
|
| LogP |
-0.9
|
| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
0
|
| Heavy Atom Count |
11
|
| Complexity |
217
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=C1NC(=O)C=2C(=N1)NNC2
|
| InChi Key |
HXNFUBHNUDHIGC-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
|
| Chemical Name |
1,7-dihydropyrazolo[3,4-d]pyrimidine-4,6-dione
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| Synonyms |
NSC 76239; NSC76239; NSC-76239
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO :< 1 mg/mL
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (8.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (8.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.25 mg/mL (8.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.5742 mL | 32.8709 mL | 65.7419 mL | |
| 5 mM | 1.3148 mL | 6.5742 mL | 13.1484 mL | |
| 10 mM | 0.6574 mL | 3.2871 mL | 6.5742 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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