Size | Price | Stock | Qty |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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Oxotremorine M iodide is a novel, potent and selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide increases the potency of NMDA receptors through both independent and dependent muscarinic receptor mechanisms.
ln Vitro |
Oxotremorine M iodide (0.1, 0.3, 1, 3, 10, 30 μM) reduces the concentration-dependent KCNQ2/3 currents[2].
Oxotremorine M iodide Phosphoinositide response to iodide is strong and has an EC50 of 0.22 μM. In mice lacking M2, M3, and M2/M3 genes, oxotremorine M iodide EC50 values are 0.36, 0.52, 1.62, and 1.48 μM, respectively[3]. |
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ln Vivo |
Oxotremorine M iodide (0.5 mg/kg; s.c.) increases dopamine (DA) release in the medial prefrontal cortex (mPFC) but has no effect in the nucleus accumbens (NAC) in male Sprague-Dawley albino rats weighing 250-350 g[4].
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References |
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Molecular Formula |
C₁₁H₁₉IN₂O
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Molecular Weight |
303.0345
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Exact Mass |
322.05
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Elemental Analysis |
C, 41.01; H, 5.94; I, 39.39; N, 8.69; O, 4.97
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CAS # |
3854-04-4
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Appearance |
Solid powder
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SMILES |
C[N+](C)(C)CC#CCN1CCCC1=O.[I-]
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InChi Key |
VVLMSCJCXMBGDI-UHFFFAOYSA-M
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InChi Code |
InChI=1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1
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Chemical Name |
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium;iodide
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Synonyms |
Oxotremorine M
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~125 mg/mL (~388.0 mM)
H2O: ~8.3 mg/mL (~25.9 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.46 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.46 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (6.46 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 7.14 mg/mL (22.16 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication (<60°C). |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.3000 mL | 16.5000 mL | 33.0000 mL | |
5 mM | 0.6600 mL | 3.3000 mL | 6.6000 mL | |
10 mM | 0.3300 mL | 1.6500 mL | 3.3000 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.