• Other

    Other
  • CN

    CN
  • EU

    EU
  • USA

    USA
    • My cart
    In the shopping cart is not goods, to choose and buy!
    • Product Name
    • Size
    • Quantity
    • Amount
      Selected items : 0 pieces Total : CHECK OUT()
      PAC-1 (VO-100)
      PAC-1 (VO-100)

      Price：
      Market Price：

      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V0025
      CAS #: 315183-21-2Purity ≥98%

      Description: First procaspase-activating compound (PAC-1; VO 100) is a small-molecule activator of procaspase-3 that directly catalyzes the maturation of procaspase-3 to the active caspase-3 by inducing the cleavage of procaspase-3 in a time-dependent manner. Study results have demonstrated that PAC-1 is able to induce cell death in both primary cancerous cells and adjacent normal tissues with 50% inhibition concentration IC50 values ranging from 0.003 to 1.41 μM and 5.02 to 9.98 μM respectively.

      References: Nat Chem Biol. 2006 Oct;2(10):543-50.

      Customer Validation
      Official Supplier of
      • VE
      • OF
      • YALE
      • hhmi
      • 香港大学
      Related Products
      Publications Citing InvivoChem Products
      • Physicochemical and Storage Information
      • Protocol
      • Quality Control Documentation
      • Related Biological Data
      • Customer Review
       Molecular Weight (MW)392.49
       FormulaC23H28N4O2
       CAS No.315183-21-2
      SynonymsPAC-1; PAC 1; PAC1; VO 100; VO-100; VO100; procaspase activating compound-1
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
       Solubility (In vitro)DMSO: 78 mg/mL (198.73 mM)
      Water:<1 mg/mL (slightly soluble or insoluble)
      Ethanol: 16 mg/mL (40.76 mM)
       Solubility (In vivo)30% PEG400+0.5% Tween80+5% Propylene glycol: 30mg/mL




      • Molarity Calculator
      • Dilution Calculator
      • The molarity calculator equation

        Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

        • Mass
        • Concentration
        • Volume
        • Molecular Weight *
        • =
        • ×
        • ×
      • The dilution calculator equation

        Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

        This equation is commonly abbreviated as: C1V1 = C2V2

        • Concentration (start)
        • ×
        • Volume (start)
        • =
        • Concentration (final)
        • ×
        • Volume (final)
        • ×
        • =
        • ×
        • C1
        •  
        • V1
        •  
        • C2
        •  
        • V2
      GeneralAdministration of PAC-1 at 5 mg with low and steady releasing significantly inhibits the growth of ACHN renal cancer xenograft in mice. Oral administration of PAC-1 (50 or 100 mg/kg) significantly retards tumor growth of NCI-H226 lung cancer xenograft in a dose-dependent manner, and markedly prevents the cancer cells from infiltrating the lung tissue.
      Animal modelMice s.c. injected with NCI-H226 (lung cancer) cells
      FormulationMixed with cholesterol and pelleted into a 3-mm-diameter 20-mg (total weight) pellet, or dissolved in a mixture of 24:1 vegetable oil/DMSO
      Dosages0, 50 or 100 mg/kg;
      Administrationp.o.; q.d., for 21 days
      References[1] Putt KS, et al. Nat Chem Biol, 2006, 2(10), 543-550.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

       

      PAC-1

      		 

      PAC-1

      评论

        Home Prev Next Last page / pices

        发评论

        ×
        Your information is safe with us. * Required Fields.
        Products are for research use only;  We do not sell to patients
        Contact Us
        Contact Us
        Tel: 1-708-310-1919
        Fax: 1-708-557-7486
        Email: [email protected]
        Frequently Asked Questions
        Subscribe to our E-newsletter
        • Name*
        • *
        • E-mail*
        • *
        • instructions：
        • *
        Copyright 2020 InvivoChem LLC | All Rights Reserved
          Site map
        prompt
        Do you confirm the receipt?