| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Patchouli alcohol (5-20 μg/mL; 24 h) not only markedly increased cell viability and decreased cellular metabolic dehydrogenase (LDH) leakage, but it also markedly increased mitochondrial membrane potential and significantly disconnected GES-1. Furthermore, patchouli alcohol can prevent inflammatory factors like MCP-1, TNF-α, and IL-6 from damaging cell mitochondria[1].
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| ln Vivo |
Patchouli alcohol (5-20 mg/kg; lateral; for 2 weeks) significantly protects the gastric mucosa from damage caused by Helicobacter pylori. Patchouli alcohol can effectively reduce oxidative stress by reducing the levels of intracellular ROS and MDA and increasing the levels of NP-SH and GSH/GSSG. Patchouli alcohol significantly inhibits the production of IL-1β, a cosmetic cell-forming chemoattractant, and IL-6 [1].
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| Cell Assay |
Cell Viability Assay[1]
Cell Types: GES-1 cells treated with Helicobacter pylori Tested Concentrations: 5 μg/mL, 10 μg/mL and 20 μg/mL Incubation Duration: 24 hrs (hours) Experimental Results: Dramatically increased cell viability and diminished cell viability Lactate dehydrogenase (LDH) leakage. |
| Animal Protocol |
Animal/Disease Models: Five to sixweeks old male C57BL/6 mice injected with Helicobacter pylori [1]
Doses: 5, 10 and 20 mg/kg Route of Administration: Oral; continued for 2 weeks Experimental Results: By reducing intracellular reactive oxygen species (ROS) and MDA, as well as increasing the levels of non-protein sulfhydryl (NP-SH), catalase and glutathione (GSH)/glutathione disulfide (GSSG), effectively alleviating oxidative stress. Excited. |
| References |
[1]. Lian DW, et al. Unraveling the Novel Protective Effect of Patchouli Alcohol Against Helicobacter pylori-Induced Gastritis: Insights Into the Molecular Mechanism in vitro and in vivo. Front Pharmacol. 2018 Nov 22;9:1347.
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| Molecular Formula |
C15H26O
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|---|---|
| Molecular Weight |
222.3663
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| Exact Mass |
222.198365449
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| CAS # |
5986-55-0
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| Appearance |
White to off-white solid
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| SMILES |
C[C@H]1CC[C@@]2([C@@]3([C@H]1C[C@H](C2(C)C)CC3)C)O
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| InChi Key |
GGHMUJBZYLPWFD-CUZKYEQNSA-N
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| InChi Code |
InChI=1S/C15H26O/c1-10-5-8-15(16)13(2,3)11-6-7-14(15,4)12(10)9-11/h10-12,16H,5-9H2,1-4H3/t10-,11+,12-,14-,15+/m0/s1
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| Chemical Name |
(1R,3R,6S,7S,8S)-2,2,6,8-tetramethyltricyclo[5.3.1.03,8]undecan-3-ol
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~449.70 mM)
Ethanol : ~20 mg/mL (~89.94 mM) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4970 mL | 22.4850 mL | 44.9701 mL | |
| 5 mM | 0.8994 mL | 4.4970 mL | 8.9940 mL | |
| 10 mM | 0.4497 mL | 2.2485 mL | 4.4970 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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