Size | Price | Stock | Qty |
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5mg |
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10mg |
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Other Sizes |
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ln Vitro |
Peimisine (17.43-92.07 μg/mL; 72 h) reveals strong cytotoxic effects [3]. Peimisine (15 μg/mL; 24, 48 and 72 hours) promotes G0/G1 phase arrest and boosts the apoptotic rate [3].
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Cell Assay |
Apoptosis analysis [3]
Cell Types: A2780 Cell Tested Concentrations: 15 μg/mL Incubation Duration: 24, 48 and 72 hrs (hours) Experimental Results: G0/G1 phase arrest of A2780 cells was induced in a time-dependent manner. Cytotoxicity assay [3] Cell Types: LLC, A2780, HepG2 and A549 Cell Tested Concentrations: 17.43-92.07 μg/mL Incubation Duration: 72 hrs (hours) Experimental Results: Inhibition of LLC, A2780, HepG2 and A549 cells, IC50 value is 20.75 μg/mL, 17.43 μg/mL, 92.07 μg/mL, 36.11 μg/mL respectively. |
References |
[1]. Pan F, et al. Peimisine and peiminine production by endophytic fungus Fusarium sp. isolated from Fritillaria unibracteata var. wabensis. Phytomedicine. 2014 Jul-Aug;21(8-9):1104-9.
[2]. Armando Alberola-Die, et al. Peimine, an Anti-Inflammatory Compound from Chinese Herbal Extracts, Modulates Muscle-Type Nicotinic Receptors. Int J Mol Sci. 2021 Oct 19;22(20):11287. [3]. Dongdong Wang, et al. Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action. BMC Complement Altern Med. 2015 Feb 21;15:29. |
Molecular Formula |
C27H41NO3
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Molecular Weight |
427.6193
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CAS # |
19773-24-1
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Related CAS # |
Peimisine hydrochloride;900498-44-4
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
O1[C@]2([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])N([H])[C@]2([H])C([H])(C([H])([H])[H])[C@]21C([H])([H])C([H])([H])[C@@]1([H])C(=C2C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[C@@]3([H])C(C([H])([H])[C@@]21[H])=O)O[H]
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~12.5 mg/mL (~29.23 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (2.92 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (2.92 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1.25 mg/mL (2.92 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.3385 mL | 11.6926 mL | 23.3852 mL | |
5 mM | 0.4677 mL | 2.3385 mL | 4.6770 mL | |
10 mM | 0.2339 mL | 1.1693 mL | 2.3385 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.